| The primary objective of this study was to examine the role of smoking and some other factors in prostate cancer progression for northeastern Ontario men. Data were collected from 461 patient charts from the Regional Cancer Program of the Sudbury Regional Hospital. The study included charts for men diagnosed with histologically confirmed primary prostate cancer (ICD-9 185) from 1996 to 1998. Multivariable logistic regression analyses were used to identify predictors of prostate cancer progression. In the current study, the results clearly demonstrated that smoking status (OR = 1.08, 95% CI: 0.75 - 1.54), did not predict prostate cancer progression among northeastern Ontario men. The number of years smoked was measured by pack-year categories (OR = 0.93, 95% CI: 0.60 - 1.46), which also did not predict prostate cancer progression for these men.;Two logistic regression models were created for smoking status and pack-year categories for cigarettes. For smoking status, the first model considered the following: family history of prostate cancer, living arrangements, body mass index (BMI), French speaking (Francophone), rurality and history of diabetes. Age at diagnosis, risk group and smoking status were also included and always retained in the model. A statistically significant difference was observed for age at diagnosis (OR = 0.64, 95% CI: 0.42 - 0.99) and for risk group (OR = 1.86,95% CI: 1.37 - 2.51). Smoking status (OR = 1.08,95% CI: 0.75 - 1.54) was entered to always be retained in the model although the difference observed was statistically non-significant. Future studies on prostate cancer progression should focus on time to progression and overall survival as results may differ in these circumstances. |
