A Clinical Study On The Treatment Of Middle-aged And Young People With Hypertension (damp-heat Syndrome) By The Method Of Clearing Heat And Removing Dampness

Objective:To observe the clinical efficacy and safety of Qingrelishijiangyayin in t he treatment of young and middle-aged patients with hypertension(damp-heat syndrom e),this paper discusses the efficacy of Qingrelishijiangyayin in the treatment of young and middle-aged patients with hypertension,and provides new ideas and effective for mulas for the treatment of traditional Chinese medicine in the treatment of young and middle-aged patients with hypertension.Were observed before and after treatment of resting heart rate and blood plasma angiotensin ?,aldosterone level changes,prelimin arily been step-down water the possible mechanism.Methods:A total of 66 patients who met the diagnostic criteria of hypertension i n young Chinese and western medicine and dampness-heat syndrome in traditional Chi nese medicine were randomly divided into the treatment group and the control group,33 cases in each group,31 cases in the treatment group and 30 cases in the control group.The control group was given western medicine valsartan dispersive tablets 40 mg qd combined with bisoprolol fumarate 2.5mg qd,and the treatment group was giv en 1 bag of bid(granules)on the basis of the control group,and the observation per iod was 4 weeks.Observation compared two groups of patients before and after medi cation clinic blood pressure,resting heart rate,angiotensin ?,aldosterone and TCM s yndrome integral,record adverse events when taking the medicine.Results:1.General information and baseline data:two groups of patients into the group of gender,age,course and grade of high blood pressure,blood pressure,restin g heart rate,angiotensin ?,aldosterone,and compares the baseline data,such as the total points of syndromes,there were no statistically significant difference(P>0.05),comparable.2.Antihypertensive effect:In terms of the total effective rate after treat ment,the total effective rate in the treatment group was 90.32%.The total effective r ate of the control group was 86.67%,and the difference was statistically significant(P<0.05).Changes of blood pressure before and after treatment:blood pressure(syst olic blood pressure and diastolic blood pressure)of the two groups were significantly lower after treatment than before treatment,and the difference was statistically signific ant(P<0.01).After treatment,the blood pressure levels(systolic blood pressure and diastolic blood pressure)of the two groups were compared,and the difference was s tatistically significant(P<0.05).3.Improvement of TCM syndromes:As for the effi cacy of TCM syndromes,the total effective rate of the treatment group was 83.87%a nd the total effective rate of the control group was 63.33%.After the treatment of si ngle symptom score of TRADITIONAL Chinese medicine,both groups significantly d ecreased(P<0.05),with statistical significance.After treatment,the single symptom scores of the treatment group were significantly different from those of the control gr oup in terms of dizziness,dizziness or headache,wan abdominal distension,loose sto ol,irritability and dry or sticky mouth or bitter mouth(P<0.05).There were no sig nificant differences in chest tightness,body weight,lack of food,insomnia,dreaminess or drowsiness(P>0.05).4.Changes of resting heart rate before and after treatment:resting heart rate of both groups decreased significantly after treatment compared wit h that before treatment,and the difference was statistically significant(P<0.01).Aft er treatment,there was no significant difference in resting heart rate between the two groups(P>0.05).5.Plasma angiotensin ?,aldosterone levels change:two groups after treatment angiotensin ?,aldosterone levels before treatment were significantly lo wer,with significant difference(P<0.01).Plasma angiotensin ? compared two grou ps after treatment,with significant difference(P<0.05).After treatment,there was n o significant difference in plasma aldosterone between the two groups(P>0.05).6.In the process of this study,no serious adverse reactions were found in both groups,and the clinical application of heat-clearing and moisture-clearing antihypertensive deco ction is safe.Conclusion:Western medicine combined with Qingrelishijiangyayin can improve t he effective rate of reducing blood pressure and further reduce the blood pressure lev el of patients.Western medicine combined been drink antihypertensive treatment can f urther decrease the plasma levels of angiotensin ?,been step-down drink can,to so me extent are activated to restrain activity of renin angiotensin system.Clearing heat,removing humidity and lowering blood pressure can significantly improve the sympto ms of dampness-heat syndrome in traditional Chinese medicine,especially in the singl e symptom of head drowsiness or dizziness or headache,abdominal distension and ful lness,loose and irritated stool,irritability and dry or sticky mouth or bitter mouth.Th e method of clearing heat and reducing humidity is an effective treatment for the hyg rothermal syndrome of hypertension in young and middle-aged people.