Clinical Study Of Shexiang Baoxin Pills In The Treatment Of Stable Angina Pectoris Of Qi Stagnation And Blood Stasis

Objective:This study aims to observe the clinical efficacy,electrocardiographic efficacy,blood lipids,serum Hcy and hs-CRP levels of Shexiang Baoxin Pill compared with Suxiaojiuxin Pill in the treatment of chronic stable angina pectoris(CSA)of qi stagnation and blood stasis type,to evaluate the clinical efficacy of Shexiang Baoxin Pill in the treatment of stable angina pectoris of qi stagnation and blood stasis type,and to verify the difference between the two drugs in improving the related symptom,and evaluate the safety of two drugs.Methods:From April 2019 to December 2019,50 patients with CSA syndrome of qi stagnation and blood stasis were enrolled in the outpatient clinics of Dongzhimen Hospital,Qian’an Traditional Chinese Medicine Hospital and Beijing Jinsong Community Health Service Center,and randomly divided into observation group(24 cases)and control group(26 cases)by random number table method.Both groups of patients were treated with conventional therapy,the observation group was treated with Shexiang Baoxin Pill,and the control group was treated with Suxiaojiuxin Pill for 14 days.After treatment,the changes of TCM syndromes,single symptoms of TCM,efficacy of angina pectoris,ECG efficacy,blood lipids,Hcy and hs-CRP levels in the two groups were observed,and safety indicators,such as blood routine,liver and kidney function,were monitored,so as to evaluate the clinical efficacy and safety of Shexiang Baoxin Pill and Suxiaojiuxin Pill.Results:(1)TCM syndrome score:Compared with before treatment,the TCM syndrome score of both groups decreased,and the difference was statistically significant(P<0.05).The total effective rate was 83.3%in the observation group and 80.7%in the control group.There was no significant difference between the two groups after treatment(P>0.05).(2)TCM single symptom score:after treatment,each single symptom score of the two groups was lower than before treatment,except for chest pain,the difference of each single symptom was statistically significant(P<0.05).In addition,there was no significant difference in each symptom score between the two groups after treatment(P>0.05).(3)Effective rate of single symptoms of traditional Chinese medicine:in improving patients’mood,the effective rate of the observation group was 87.5%,and that of the control group was 65.3%,the difference was statistically significant(P<0.05);in improving patients’ chest and hypochondrial distension pain,86.6%of the observation group and 57.8%of the control group;the difference was statistically significant(P<0.05).There were no significant differences in chest tightness,good rest,dark lips and pulse signs(P>0.05).(4)ECG efficacy:the effective rate of ECG in the observation group was 33.3%,and that in the control group was 23%.There was no significant difference in ECG efficacy between the two groups after treatment(P>0.05).(5)Lipids:There was no significant difference in TC,TG,HDL and LDL levels between the two groups before and after treatment(P>0.05).(6)Hcy level:there was no significant difference between the observation group and the control group after treatment(P>0.05);hs-CRP level:there was no significant difference between the two groups after treatment(P>0.05);(7)Safety comparison:the two groups of patients did not complain of any obvious discomfort after treatment,ALT,AST,UA in both groups before and after treatment were within the normal range,and there was no significant difference before and after treatment(P>0.05).Conclusion:(1)Shexiang Baoxin Pill and Suxiaojiuxin Pill have good clinical efficacy in improving TCM syndromes,TCM-related symptoms and angina pectoris in CSA patients with qi stagnation and blood stasis.(2)in improving mood,chest and hypochondrium swelling pain,Shexiang Baoxin Pill is superior to Suxiaojiuxin Pill.Shexiang Baoxin Pill is superior to Suxiaojiuxin Pill in improving angina pectoris with obvious Qi stagnation,so it is more recommended to use Shexiang Baoxin Pill for emotionally induced angina pectoris.(3)Shexiang Baoxin Pill and Suxiaojiuxin Pill have no obvious toxic side effects and adverse reactions in the treatment of stable angina pectoris,and they are safe and reliable.