| Objective:Study the bone mineral density and fracture probability of RA patients,and analyze the bone mineral density of different TCM syndromes in RA patients,so as to provide a reference for the treatment of osteoporosis in the clinic.Methods:This study investigated patients with RA all met the requirements of the subject.Under the guidance of the investigator,the patients who participated in the study were asked to fill out the questionnaire.Use the information from questionnaire,obtain relevant data such as bone mineral density,major TCM syndromes,and calculate the fracture probability of the patient.Finally,the data obtained by it is statistically analyzed.Results:1.General information:Among the 141 RA patients surveyed,56.74%were patients aged 60 years and younger,43.26%were patients over 60 years old,88.65%were women,11.35%were men.The prevalence of osteoporosis was 37.58%.2.Clinical data of patients with syndromes of RA:①Dampness heat and stasis blockage is the most common type of syndrome among all patients.②Osteoporosis in RA patients with different syndromes:Sick person over the age of 60 were compared in age,P>0.05,the difference was not statistically significant.Sick person over the age of 60 were in contrast to osteoporosis and non-osteoporosis,P<0.05,the difference was statistically significant.In the incidence of osteoporosis,liver and kidney deficiency group>qi and blood deficiency group>damp heat and stasis blockage group>wind cold dampness stasis group.After the two-to-two comparison,wind cold dampness stasis and qi and blood deficiency,P<0.05,the difference was statistically significant.Wind cold dampness stasis and liver and kidney deficiency,P<0.05,the difference was statistically significant.Four groups of postmenopausal patients were compared inage,P>0.05,the difference was not statistically significant.Postmenopausal sick person were in contrast to osteoporosis and non-osteoporosis,P<0.05,the difference was statistically significant.In the incidence of osteoporosis,liver and kidney deficiency group>qi and blood deficiency group>damp heat and stasis blockage group>wind cold dampness stasis group.After the two-to-two comparison,wind cold dampness stasis and liver and kidney deficiency,P<0.05,the difference was statistically significant.③ Comparison of various factors in patients with different syndromes of RA:Among the 141 RA patients surveyed,the patients with excess and deficiency syndrome were compared in age and previous fracture,P<0.05,the difference was statistically significant.Sick person were compared in age,P<0.05,the difference was statistically significant.After the two-to-two comparison,dampness heat and stasis blockage and qi and blood deficiency,P<0.05,the difference was statistically significant.Sick person were compared in fracture,P<0.05,the difference was statistically significant.After the two-to-two comparison,wind cold dampness stasis and liver and kidney deficiency,P<0.05,the difference was statistically significant.Dampness heat and stasis blockage and liver and kidney deficiency,P<0.05,the difference was statistically significant.3.Comparison of clinical data between patients with osteoporosis and non-osteoporotic RA:Sick person were compared in age,height,weight,duration of disease,lumbar spine and femoral neck bone density,H and M,P<0.05,the difference was statistically significant.Female sick person were in contrast to menopause,P<0.05,the difference was statistically significant.4.Logistic regression analysis:Patients over 60 years old had an increased risk of osteoporosis compared with patients aged 60 years and younger(OR=2.775 95%CI:1.249-6.165);patients with a disease duration of more than 5 years were compared patients with a disease duration of 5 years or less have an increased risk of osteoporosis(OR=6.61795%CI:2.810-15.582);patients with BMI>24kg/m2 have a lower risk of osteoporosis than patients with BMI<24kg/m2(OR=0.351 95%CI:0.147-0.838).There was no regression relationship between OP and menopause in women with RA.Conclusion:1.The most patients with dampness heat and stasis blockage syndrome.2.The incidence of osteoporosis in patients with RA over 60 years old was significantly different between the four groups of wind cold dampness stasis,dampness heat and stasis blockage,qi and blood deficiency,and liver and kidney deficiency.The incidence of osteoporosis in postmenopausal RA patients was significantly different between the sick person with wind cold dampness stasis,dampness heat and stasis blockage,qi and blood deficiency,and liver and kidney deficiency.3.Patients with RA combined with OP were older,had lower height and weight,longer duration,lower BMD of lumbar spine and femoral neck,and greater probability of fracture and women have a greater proportion of menopausal patients.4.Older age and longer course of disease were risk factors for patients.High BMI was a protective factor for patients. |
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