Clinical Phenotype Data And Lipid Peroxidation Study Of Non-alcoholic Fatty Liver Disease With Accumulation Of Damp-heat

BackgroundNon-alcoholic fatty liver disease(NAFLD)is a metabolic stress liver injury associated with insulin resistance and lipid peroxidation damage.With the changes in modern eating habits and the increase in metabolic diseases such as obesity,the prevalence of NAFLD has increased year by year.Purpose and significanceComparing the differences in clinical phenotypic data and serum lipid peroxidation injury indicators between NAFLD patients with moisture and heat accumulation syndrome and healthy volunteers in health-examined individuals,summarizing the characteristics of NAFLD with moisture and heat accumulation syndrome,and providing reasonable suggestions and basis for clinical diagnosis and treatment.Objectives and methodsFrom September 2017 to March 2018,the NAFLD patient volunteers with moisture and heat accumulation syndrome were recruited as a case group in the Physical Examination Center of the China-Japan Friendship Hospital.At the same time,healthy volunteers were recruited as the control group.The clinical phenotypic data of the volunteers were obtained by filling out and checking the physical examination report,and the serum samples of the volunteers were collected to detect the lipid peroxidation injury index.Use Excel to create a database and enter data;use SPSS20.0 software to organize and statistically analyze the data.Research result1 Demographic data A total of 97 valid questionnaires were collected.There were 68 cases in the case group and 29 cases in the control group.In the case group,41 males(60.3%)and 27 females(39.7%)had an average age of 38(29,45)years.There were 10 males(34.5%)in the control group and 19(65.5%)females with an average age of 31(25,31)years.2 Body Mass Index(BMI)The mean BMI of the case group was 28.3±3.38(kg/m2),8 cases of BMI were in the normal range,60 cases were higher than the normal range,including 22 cases of overweight range(24.0≤BMI<28.0),and 38 cases of obesity range(BMI≥28.0).The mean BMI of the control group was 20.3±2.38(kg/m2),and the BMI was 2 cases of overweight.There was a significant difference in BMI between the case group and the control group(P<0.001).In the non-obese group,30 patients with NAFLD,29 patients with non-NAFLD,and 38 patients with obesity were patients with NAFLD.There was a significant difference in the proportion of NAFLD between the two groups(P<0.001).3 waistlineThe average waist circumference of males in the case group was 99.09±9.88(cm),and the average waist circumference of the control group was 80.27±2.38(cm).In the case group,the average waist circumference was 95.35±9.58(cm),and the average waist circumference of the control group was 69.06±6.24(cm).There was a significant difference in waist circumference between the case group and the control group(P<0.001 for both males and females).4 Waist to hip ratioIn the case group,the average waist-to-hip ratio of males was 0.90±0.04,and the average waist circumference of the control group was 0.82±0.05.In the case group,the average waist circumference of women was 0.93±0.06,and that of the control group was 0.75±0.04.There was a significant difference in the waist-to-hip ratio between the case group and the control group(P<0.001 for both males and females).5 Diet and lifestyleThere was a statistical difference in the diet taste and diet match between the case group and the control group.The frequency of the case group was higher than the control group in the case of eating sweet food,frying,and foraging,but there was no statistical difference in regular diet,smoking,and exercise.In the food classification,the two groups had statistical differences in eating fried foods,carbonated drinks,and meat(pork-based).The frequency of eating fried,carbonated drinks,and meat(pork-based)in the case group was higher than that of the control group.There was no statistical difference in dry fried food,fish,pepper,miscellaneous grains,vegetables,coffee,and soy milk.6 General serum biochemical indexThe mean values of biochemical indicators in the case group and the control group were within the normal range,but the two groups had statistical differences in CHO,TG,LDL-C,HDL-C,GLU,AST,ALT,ALP,GGT,UA,and the case group in terms of CHO,TQ LDL-C,GLU,AST,ALT,ALP,GGT,UA,it was higher than the control group,and it was lower than the control group in HDL-C.Further analysis was performed on the abnormal rate of biochemical indicators with statistical differences.There were statistical differences in the abnormal proportions of CHO,TQ LDL-C,ALT,GGT,and UA between the case group and the control group.6 serum peroxidation damage metabolitesThere were statistical differences in serum 8-Iso-PGF2α,MDA and LTB4 between the case group and the control group,and the detection level of the case group was higher than that of the control group,but there was no statistical difference in serum 4-HNE levels between the two groupsConclusion and significance1.NAFLD patients with moisture and heat accumulation syndrome are generally obese and predominantly abdominal obesity;the risk of NAFLD from physique assessment cannot be based solely on BMI,and the measurement of waist circumference should be emphasized.2.Eating habits are risk factors for NAFLD with moisture and heat accumulation syndrome.Patients should be educated to reduce their preference for diet,such as sweetness,frying,foraging(pork-based),carbonated drinks,and pay attention to dietary structure.3.NAFLD with moisture and heat accumulation syndrome is an important reason for the increase of general serum biochemical indicators in healthy people.4.Lipid peroxidation damage is present in the NAFLD with moisture and heat accumulation syndrome of health-examined individuals.