Study On Naoan Dropping Pills In The Treatment Of Migraine With Clinically Adapted Symptoms

BackgroundMigraine is a kind of recurrent and throbbing headache,which generally break out unilaterally,and often accompany with nausea and vomiting.Before the onset of headache,a few visual,sensory signs and motor disorders may occur,and some patients can have a family history.In China,the prevalence of migraine is about 9.3%.The disability of migraine is high,and patients of migraine confront a heavy burden.Additionally,migraine with aura is a risk factor of ischemic stroke and cerebral white matter lesions.Patients of migraine have a lower living quality than other people.The prevention and treatment of migraine have aroused wide attention in the medical community:Moreover,treatment for headache through Chinese medicine has a long history,with a wealth of clinical experience.Study on the Clinical Adaptation Symptom Group of Treatment of Migraine with Naoan Pills is part of the multidisciplinary clinical study of Naoan pills in the treatment of clinical symptoms of migraine.In accordance with the International Headache Association,migraine clinical research guidelines" requirements,designed a prospective multi-center clinical research program.PurposeTo further evaluate the clinical efficacy and safety of Naoan pills in the treatment of migraine headache;To further explore the clinical symptom groups of Naoan pills for the treatment of migraine.MethodThis study uses a multi-center,prospective design.Naoan pills is a drug for the treatment of stroke sequelae,because the reported less early literature of Naoan pills,so the number of test samples to determine the reference to other drugs.Mainly through the outpatient and advertising recruiting way to collect patients,meet the inclusion criteria of patients first signed informed consent,and physical and chemical examination,check the results of eligible patients before admission.Oral Naoan pills,each 20,2 times a day,taking 4 weeks;into the group issued 1 day,the drug is 4 weeks to take the amount of 4 weeks after the end of treatment,8 weeks follow-up 1 times.SPSS 20.0 statistical software package for statistical analysis.All the statistical tests were used bilateral t test,P<0.05 that the difference was statistically significant,P<0.01 as a highly significant statistically significant.The primary outcome measures were the percentage of headache episodes,the number of episodes of the number of headache attacks,the number of days,the duration and patient report outcome(PRO).ResultThe main efficacy indicators:treatment 4 weeks to follow-up 4 weeks,8 weeks,the nunber of patients with headache episodes decreased by half,and showed an increasing trend(P≤0.05)the difference was statistically significant.Indicating that Naoan pills in the treatment period and follow-up period can significantly reduce the number of headache attacks,long-term efficacy than the recent good effect.Secondary efficacy indicators:1.4 weeks of treatment,4 weeks and 8 weeks of follow－up compared with the former group before treatment,the number of headache attacks,the number of days were reduced,Headache attack days reduced by half increased(P<0.05).2.4 weeks of treatment,4 weeks and 8 weeks of follow-up compared with the former group before treatment,the headache attack,mental state,functional status and PRO total score were decreased;3.4 weeks of treatment,4 weeks and 8 weeks of follow-up compared with the former group before treatment,Tanshi syndrome,Yuzheng syndrome,Qixu syndrome,Yinxu syndrome,Yangxu Syndrome scores have declined.Clinical adaptation symptoms cluster of Naoan pills:Migraine four diagnostic information,the core symptoms(that is,the frequency of the first 7 symptoms):quiet relief,poor sleep worse,light dark relief,tired increase,intolerance fatigue.Reference symptoms(that is,the frequency is equal to or more than 4 times but the order after the 7-bit after the symptoms):cold heavier,pain,thinking increased,increased mental stress,afternoon attack,side headache,Sleepy sleepiness,pain is set.Tongue like red tongue,dark tongue and purple tongue-based,accompanied by water moss,greasy moss-based.Pulse to the slow pulse based on the main.Migraine treatment for 4 weeks compared with before treatment,migraine headache in the various symptoms of migraine,the treatment is efficient when starting and ending impermanence,no headache when the dark light can be alleviated and sometimes light and sometimes heavy(P<0.05).Migraine headaehes were followed up for 8 weeks compared with before treatment,migraine headache with no top headache,breast tenderness,plenty of dreams,treatment is efificiency(P<0.05).ConclusionNaoan pills in the improvement of migraine patients with the disease and syndrome has a certain effect.l.Naoan pills in the treatment of migraine headache(4 weeks of treatment,followed up for 4 weeks,8 weeks)is efficiency.2.Naoan pills in the treatment of Tanshi syndrome,Yuzheng syndrome,Qixu syndrome,Yinxu syndrome,Yangxu syndrome,the effect is significant.Reflects the Naoan pills to improve the advantages of Chinese medicine syndromes.3.The effect of Naoan pills treat migraine is high when the headache is light or weight,starting and ending impermanence,no top headache,breast pain and more dreams.