Research Progress Of Amplitude Integrated Electroencephalogram(aEEG) Applied In The Early Diagnosis Of Brain Damage Of Late Premature Infant

Objective: To discuss the application value of amplitude integrated electroencephal ogram(a EEG)in the early diagnosis of brain damage of late premature infant.Methods:(1)eighty late premature infants with high risk of brain damage that were admitted to our hospital between August,2018 to August,2019 were enrolled in this research.They were divided into two groups of brain damage(35 cases)and non brain damage(45cases)according to their brain magnetic resonance imaging(MRI)results and neurological symptoms.(2)AEEG monitoring was performed in both groups within 72 hours after birth,and brain MRI was performed within 2 weeks after birth.Neonatal behavioral neurological assessment(NBNA)was conducted at corrected age of 40 weeks,while Gesell developmental schedules test was conducted at corrected age of 6 months.(3)The premature infant scoring system was used for scoring.After correction,the total score was divided into the mean score of the corresponding gestational week premature infants minus the original score.Analyze two groups results of the scores of a EEG?the total score of a EEG after correction?brain MRI?NBNA and Gesell developmental schedules test to discuss the correlation of abnormal a EEG results ? early diagnosis of brain damage of late premature infant and the development of recent nervous system.Results:(1)The score of continuity of background activity?the sleep-wake cycles? the amplitude of the lower boundary ? variation of spectral band width and lower boundaryamplitude,scores of a EEG monitoring parameters in brain damage group were significantly lower than those in non brain damage group,and the difference was statistically significant(P<0.05).(2)The total score of a EEG after correction in brain damage group was higher than that in non brain damage group,and the difference was statistically significant(P<0.05).(3)The results of brain MRI showed that the positive rate of severe a EEG abnormality group(83.33%)was significantly higher than that of mild a EEG abnormality group(47.4%),which was statistically significant(P<0.05).(4)The scores of NBNA and Gesell test in mild a EEG abnormality group were higher than those in severe a EEG abnormal group,and the difference was statistically significant(P<0.05).Conclusion:(1)The scores of a EEG monitoring parameters and the total scores after correction and late premature infant brain damage were related.Compared to non brian damage group,brain damage group showed poorer continuity of background activity,while the sleep-wake cycles were more immature and the amplitude of the lower boundary decreases.Meanwhile,the total scores after correction were higher.(2)There was a positive correlation between the abnormal degree of a EEG monitoring and the results of brain MRI.The higher the abnormal degree of a EEG,the higher the positive rate of brain MRI.a EEG can be used in the brain damage of late premature infant.(3)There was a negative correlation between the abnormal degree of a EEG and NBNA and Gesell test scores.The more abnormal the a EEG,the lower of the two test scores.This indicate that early stage a EEG examination can be predictive for recent development of nervous system of the late premature infant.(4)AEEG can be used for early routine examination of brain damage in late premature infant.Regular follow-up and assessment of neurological development can be carried out for those with abnormalities,to seek for early diagnosis,early treatment and prognosis improvement.