Preliminary Clinical Study On Drug Eluting Beads Transarterial Chemoembolization For The Treatment Of Unresectable Colorectal Liver Metastases

Objective: The safety and efficacy of drug eluting beads(DEB)transarterial chemoembolization(DEB-TACE)for the treatment of unresectable colorectal cancer liver metastaseswere evaluated by analyzing initial clinical data.Methods: From January 2018 to April 2020,26 patients with unresectable liver metastases were treated with 100-300 um of Callispheres drug-eluting beads loaded with 100 mg irinotecan for DEB-TACE treatment.After treatment,modified-RECIST criteria were used to evaluate the short-term efficacy of 3 months and 6 months after operation;clinical complications were recorded and graded;and changes in blood routine,liver function and tumor markers were statistically analyzed before,1 week after and 1 month after operation.RESULTS :26 patients underwent DEB-TACE treatment40 times.The CR、PR、SD、PD of March and June using the modified-RECIST assessment were :0%、61.5%、34.7%、3.8% VS 0%、53.8%、23.1%、23.1%.The objective response rate(ORR)and disease control rate(DCR)in March and June were 61.5%、96.2%VS 53.8%、76.9%.Before and after 1 week,1 month of blood biochemical index statistical analysis results suggest: the difference of ALT before and after 1 week after operation was extremely significant(p=0.001);the difference in CEA of tumor markers before and 1month after operation was extremely significant(p=0.001);there was no significant difference in other blood routine and liver function indicators(P>0.05).The patient was followed up from 8 to 19 months(average 9mongth).One patient developed biliary tract infection secondary to bile tumor at 6 months of follow-up resulting in patient death.Conclusion: This preliminary clinical study confirmed the safety and efficacy of Callispheres drug eluting beads transarterial chemoembolization for the treatment of unresectable colorectal liver metastases 。 However,the medium and long-term effects need to be followed up.