| Objective:This study explores the clinical effect of Chong Amaranth Decoction on blood-heat facial and facial hormone-dependent dermatitis by observing more comprehensive and objective changes in symptoms and rashes,and analyzes the legislative basis and modern pharmacological mechanism of action of the self-made prescription to make it Scientific and reasonable application to the clinic.Methods:The observed cases in this study were all from the Dermatology Clinic of the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine from February 2019 to December 2019.A total of 65 patients diagnosed with blood-heat type facial hormone-dependent dermatitis were enrolled,and they were randomly divided into a treatment group of 32 cases and a control group of 33 cases.In the whole study,the Visia skin tester and artificial scoring method were used to comprehensively and objectively evaluate the therapeutic effect of Chong Amaranth Decoction on hormone-dependent dermatitis of blood-heat facial faceTreatment group:Recombinant bovine basic fibroblast growth factor(bFGF)for external use Trade name:Bei Fuji;Production company:Zhuhai Yisheng Biopharmaceutical Co.,Ltd.;Batch number:National Medicine Standard S10980076;Specifications:21000IU/5g/piece)and polysulfonic mucopolysaccharide cream(trade name:Xiliaotuo;production company:Mobilat Produktions GmbH;batch number:H20110296;specification:40g/piece),in conjunction with the self-made heavy amaranth decoction wet compress,Recipe composition:9g Chonglou,30g Forsythia,Portulaca 30g,Scutellaria baicalensis 30g,Peppermint 10g,Cortex Moutan 15g,White fresh peel 15g,Radix Digupi 15g.(The granule dosage form is produced and provided by Beijing Kangrentang Co.,Ltd.)Usage:prepare 300ml of boiling water and add it to the granule,let it cool to room temperature,dip six layers of gauze into the liquid of Chinese medicine,twist until the gauze does not drip,and apply the gauze to the affected area.After 15 minutes,apply recombinant bovine basic fibroblast growth factor and use polysulfonic mucopolysaccharide cream.Twice a day,continuous medication,the course of treatment is 28 daysControl group:Wet compresses with clean water,and recombinant bovine basic fibroblast growth factor followed by polysulfonic mucopolysaccharide cream.Usage:First wet compress with clean water,and then externally use recombinant bovine basic fibroblast growth factor and polysulfonic mucopolysaccharide cream,twice a day,continuous medication,the course of treatment is 28 daysObservation methods:① After treatment,the two groups of subjects gave Visia pictures of the whole part for comparison before and after,and performed Visia full-face skin analysis.The researchers objectively recorded the absolute scores of the red areas of the face,ultraviolet spots,and texture.②Researchers objectively record patient data and adverse reactions according to the clinical observation table in the appendix according to the condition of the tested patients.③The researcher objectively recorded the data according to the description of the subjects according to the dermatological quality of life index scale in the appendix.④ Follow-up records of patients were followed up 8 weeks after the end of treatment,and the efficacy of the two groups was compared during the follow-up.Evaluation index:Refer to the "Guidelines for Clinical Research of New Drugs of Traditional Chinese Medicine"(2002 edition)and relevant literatures in recent years to formulate the syndrome score standard,including 4 types of skin damage indexes and 4 types of symptom indexes,the 4 types of skin damage indexes are erythema and papules Pustule-like,swollen,desquamative;4 symptom indicators are itching,tightness or dryness,tingling sensation,burning sensation,each index is judged as none,light,medium,Heavy,with 0,1,2,and 3 points,respectively.Statistical method:Use SPSS21.0 statistical software to analyze and sort the data.Count data are described by the number of cases and percentage(%),and statistical inferences between groups are tested by 2;measurement data use mean±standard deviation(x±s)Description:The independent sample t test was used for the comparison between groups,the paired sample t test was used for the comparison before and after treatment within the group,and the non-parametric rank sum test was used for the comparison of grade data between groups;the difference was statistically significant when P<0.05.Result:1.Efficacy:Compared with the total score of symptoms before and after treatment in the treatment group and the control group,the difference between the two groups before treatment was not statistically significant(P>0.05),the difference between the two groups was statistically significant 7 days after treatment and 28 days after treatment(P<0.05),the treatment group received 8.47±2.64 points,3.94±2.28 points after 7 days and 28 days of treatment,the control group had 10.30±2.07 points,5.97±3.02 points after 7 days and 28 days of treatment,and the treatment group The total score of symptoms was significantly lower than that of the control group.In terms of skin lesions,the treatment group had better improvements in erythema,papule pustules,desquamation,and swelling than the control group,and the difference was statistically significant(P<0.05).In terms of efficiency and number of effective cases,after 28 days of treatment,the total effective rate of the treatment group was 93.55%,of which 3 cases were cured,22 were markedly effective,4 were effective,and 2 were ineffective;the total effective rate of the control group was 89.66%,of which 1 was cured In 13 cases,markedly effective in 12 cases,effective in 12 cases,and ineffective in 3 cases,the effective rate of the treatment group was higher than that of the control group,and the total effective rate between the two groups was statistically different(P<0.05).2.The symptom improvement of the two groups:the difference between the two groups before treatment was not statistically significant(P>0.05);the scores of tingling sensation and burning sensation in the treatment group 7 days after treatment were 0.84±0.64 points and 0.84±0.90 points,respectively.,Significantly lower than the control group’s 1.21 ±0.73 points and 1.28±0.60 points,the difference between the two groups was statistically significant(P<0.05);28 days after treatment,the scores of tingling and burning sensation in the treatment group were 0.29±0.53 points,0.29±0.53 points,significantly lower than the control group’s 0.66±0.77 points and 0.62±0.62 points,the difference between the two groups was statistically significant(P<0.05);the two groups were tight at 7 and 28 days after treatment Or the dryness symptom scores were significantly decreased,the itch symptom scores were not significantly decreased,and there was no statistically significant difference between the two groups(P>0.05).3.Visia test results:There was no statistically significant difference between the groups before UV treatment,1 week after treatment,and 4 weeks after treatment(P>0.05);there was no statistical difference between the red area before treatment and 1 week after treatment Significance(P>0.05),3.16±0.93 points in the treatment group after 28 days of treatment,significantly lower than 3.83±1.14 points in the control group,the difference between the two groups was statistically significant(P<0.05);there was no difference between the texture indexes before treatment Statistical significance(P>0.05).After 7 days of treatment and after 28 days of treatment,the treatment group was 3.87±1.96 and 3.16±1.55,which was significantly lower than the control group’s 5.04±1.97 and 4.83±1.79.The difference between the two groups was statistically significant Significance(P<0.05).4.Quality of life:Dermatology life quality index(DLQI)is widely recognized internationally for dermatological patients to investigate the quality of life of patients.The quality of life scores of the treatment group after 7 days and 28 days were 10.07±2.29 points and 5.61 ±2.26 points,respectively,and the quality of life scores of the control group after 7 days and 28 days were 12.79±2.04 points and 8.35±2.82 points,respectively.The quality of life scores in the treatment group were significantly lower than those in the control group.The difference was statistically significant(P<0.05).Conclusion:1.The heavy amaranth decoction wet compresses the treatment of blood-heat type facial hormone-dependent dermatitis.It has obvious effect on erythema,papules,pustules,desquamation,swelling,Visia red area and texture absolute score,tingling sensation,burning sensation,and has obvious effect.Obvious adverse reactions occur,and the safety is relatively high2.Chongyi Decoction wet compress has obvious effect in improving the quality of life of patients. |
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