| Objective:Based on the theory of gasification,this study deeply explores Li Dongyuan’s academic thoughts and interprets his ideas on formulated prescription.In this way,the effectiveness of the prescription in the treatment of phlegm-dampness syndrome of coronary heart disease was observed,so as to provide new ideas for the treatment of phlegm-dampness syndrome of coronary heart disease.Methods:Consult the ancient and modern doctors on the theory of gasification,learn the theoretical basis of gasification;By reading Li Dongyuan’s books on Pi Wei Lun,Lan Shi Mi Cang,and Nei Wai Shang Bian Huo Lun,combining with his teacher Zhang Yuansu’s academic thoughts,this paper explores li dongyuan’s ideas of forming a way with the theory of gasification.This paper discusses the relationship between the formation of phlegm-dampness syndrome of coronary heart disease and the disregulation of gasification.From December 2018 to December 2019,the patients with phlegm dampness syndrome of coronary heart disease diagnosed and treated by the cardiovascular department of the Second Affiliated Hospital of Tianjin University of traditional Chinese medicine were collected and included in the clinical trial after obtaining the informed consent of the patients;randomly divided into treatment group and control group,the ratio of cases is 1:1.The control group was treated with conventional Western medicine,and the treatment group was treated with conventional western medicine plus self-designed resolving phlegm-dampness and removing arthralgia formula for 4 consecutive treat weeks,a total of 28 days.Before and after treatment,both groups filled in general condition questionnaire,angina symptom quantification score form,TCM syndrome quantification score form,safety index monitoring form.Before treatment,homogeneity test was conducted between groups to ensure that there was no statistical difference in general condition and main observation indexes between the control group and the treatment group,which was comparable.After 4 weeks,the clinical improvement was observed,and the clinical effect and safety of the treatment ofphlegm-dampness syndrome of coronary heart disease with the self-designed resolving phlegm-dampness and removing arthralgia formula based on the gasification theory were evaluated.Results:(1)Gasification is a variety of life phenomena generated by life on the basis of natural climate change,which is generally divided into natural gasification,human gasification and drug gasification.Li Dongyuan believes that the gasification of human body is the same as that of universe,which also follows the principle of rising and falling cycle.And the medicine through its own smell Yin and Yang,rise and fall floating characteristics,can correct the human body gasification prosperity and decline.It is of great significance to study the theory of human body gasification and drug gasification.(2)Li Dongyuan lived during jin to yuan dynasty with a strong academic atmosphere but frequent wars.During the same period,many excellent doctors with complete academic theories,distinct views and abundant works,such as liu wandu and zhang xuanyuan,emerged.Such fertile soil created li dongyuan’s academic achievements.Li Dongyuan attaches great importance to the study of classic works such as the Nei Jing,with profound theoretical foundation,and pays special attention to the correspondence between man and nature.Under the guidance of the corresponding theory of man and nature,he enriched and improved the theory of the use of medicine in the time of law,and studied the five movements and six qi deeply.In the treatment of diseases,Li Dongyuan paid attention to the adjustment of the rise and fall of the body’s qi mechanism.He established the theory of spleen and stomach,which emphasized the importance of spleen and stomach in the process of qi movement and transformation,and pay attention to the combination of human body gasification and drug gasification.(3)The occurrence of phlegm and dampness syndrome of coronary heart disease is mainly due to the disregulation of gasification of the human body and the maladjustment of the rise and fall of the Qi,which eventually leads to the generation of phlegm and dampness and the obstruction of the heart.The treatment of this disease should be to correct the imbalance of gasification,remove the main cause of the disease,in order to restore the normal gasification of the human body.(4)In this clinical observation,60 cases were completed,including 30 in the treatment group and 30 in the control group.After this clinical observation and treatment,the improvement of angina symptoms and ECG in the treatment group was better than that in the control group according to the relevant efficacy evaluation standards of this test,with a statistically significant difference(P < 0.05).The blood lipid in the treatment group was also improved to some extent.The levels of TC and LDL-C were lower than that before treatment(P < 0.05),and the levels of HDL-C were higher than that before treatment(P < 0.05)The HDL-C level in the treatment group was higher than that in the control group(P < 0.05).(5)After this clinical observation and treatment,the total score of TCM syndrome in the treatment group was significantly improved compared with that before treatment(P < 0.01).Compared with the control group,the total effective rate of TCM syndrome in the treatment group was better than that in the control group,the difference was statistically significant(P <0.05).In the treatment group,the improvement of chest tightness,tongue quality,tongue coating,body weight,mouth viscosity,stool viscosity,fullness of abdominal distention,drowsiness and stupidity were better than those in the control group(P < 0.05).Comparison before and after treatment,chest pain,chest distress,tongue quality,tongue coating,limb sleepiness,mouth mucus,stool mucus,fullness of epigastric distention,dark complexion,drowsiness and stupidity in the treatment group were significantly improved(P < 0.01).Before and after treatment,the distribution of tongue and pulse in the treatment group was significantly different from that in the control group(P < 0.05).(6)In this clinical observation,the patients in the treatment group did not have abnormal changes in safety indicators and no serious adverse events during the treatment period,so the self-designed resolving phlegm-dampness and removing arthralgia formula is safe in the treatment of this disease.Conclusion:This paper interprets Li Dongyuan’s idea of composition from the theory of gasification.It enriches and develops the application of gasification theory in clinical practice,and makes the theory of gasification from nature to human body,from theory to clinical practice.It widens the interpretation thinking of Li Dongyuan’s academic thought,and under the guidance of the corresponding theory of heaven and man,excavates and combs the specificapplication of gasification theory in Li Dongyuan’s prescription thinking.The application of Li Dongyuan’s Qi Theory in the treatment of phlegm dampness syndrome of coronary heart disease can significantly improve the clinical symptoms and phlegm dampness related syndrome,comprehensively improve the quality of life of patients,with definite curative effect and good safety,and provide a new idea for the treatment of phlegm dampness syndrome of coronary heart disease. |
PDF Full Text Request