Correlation Analysis Of Bilirubin And Uric Acid Levels With Carotid Plaque Formation In Patients With Type 2 Diabetes Mellitus

ObjectiveTo observe the changes of serum bilirubin(BIL),serum uric acid(SUA)and carotid plaque formation(CPF)in patients with type 2 diabetes mellitus(T2DM),analyze the risk factors of CPF,and explore the correlation between BIL,SUA and CPF.MethodThe general clinical data of 123 T2 DM patients in the Department of Endocrinology and metabolism,China Japan Friendship Hospital,Jilin University from January 2019 to December 2019 were collected,including gender,age,biochemical indicators,etc.According to the measured carotid intima media thickness(IMT),54 cases were divided into simple T2 DM group,69 cases in T2 DM with carotid atherosclerotic plaque group(IMT ≥ 1.5mm)and 30 cases in healthy control group.The serum uric acid(SUA),total bilirubin(TBIL),direct bilirubin(DBIL),indirect bilirubin(ibil)and other laboratory indexes were measured by biochemical instruments in the laboratory of our hospital.Spss19.0 software was used to analyze the data.P < 0.05 means the difference is statistically significant.Result1.Compared with SBP,FBG,2hPBG,HbA1 c,TC and TG,the level of T2 DM group was significantly higher than that of healthy control group;compared with 2hPBG,HbA1 c and TG,the level of T2 DM group with carotid atherosclerotic plaque was significantly higher than that of T2 DM group;compared with age,SBP,DBP,FBG,2hPBG,HbA1 c,TC and TG,the level of T2 DM group with carotid atherosclerotic plaque was significantly higher than that of healthy control group.2.The levels of TBIL and IBIL in healthy control group,T2 DM group and T2 DM with carotid atherosclerotic plaque group decreased gradually,while the levels of SUA in the three groups increased in turn;while the levels of DBIL in T2 DM group and T2 DM with carotid atherosclerotic plaque group were significantly higher than those in healthy control group.3.Logistic regression analysis showed that fasting blood glucose,blood uric acid and triglyceride were independent risk factors for carotid plaque formation in T2 DM patients.Conclusion(1)T2DM patients with carotid atherosclerotic plaque 、 T2 DM patients compared with healthy people,the levels of total bilirubin and indirect bilirubin decreased,while the levels of direct bilirubin and blood uric acid increased.(2)Fasting blood glucose,uric acid and triglyceride are independent risk factors for carotid plaque formation in T2 DM patients.