Impact Of Obstructive Sleep Apnea/hypopnea Syndrome On Thyroid Function

Objective : Obstructive sleep apnea/hypopnea syndrome(OSAHS)is closely associated with thyroid function.This study analyzed the effects of OSAHS on thyroid function based on inflammatory indicators.Methods:Based on the apnea/hypopnea index(AHI),305 OSAHS patients were divided into a non-OSAHS group,mild OSAHS group,moderate OSAHS group,and severe OSAHS group.Basic patient information,routine blood analysis results,six thyroid function parameters,inflammation indicators,and sleep monitoring data were compared among the groups.Results:Compared to the non-OSAHS group,OSAHS groups had a significantly greater proportion of hypothyroidism and erythrocyte hemoglobin distribution width(PDW)(P<0.05).Spearman’s rank correlation test implied that PDW was significantly correlated with the AHI(r = 0.188;95% CI 0.074–0.297,P = 0.001)and oxygen desaturation index(r = 0.149;95% CI 0.034–0.260,P = 0.009).Thyroid function analyses showed that patients with hypothyroidism had higher levels of PDW than patients with normal thyroid function in the severe OSAHS group(P = 0.001).PDW was significantly and positively correlated with thyroid stimulatory hormone(r = 0.148;95% CI 0.032–0.259,P = 0.001).Conclusions:This study revealed that OSAHS is significantly associated with an increased risk of hypothyroidism.When OSAHS becomes severe,the likelihood of hypothyroidism is significantly increased.This study showed that the inflammatory index,PDW,was correlated with the severity of OSAHS.OSAHS-induced thyroid function impairment may be associated with PDW.