The Clinical Features Of Preeclampsia Complicated Fgr

Background and purpose:Severe preeclampsia with fetal growth restriction has attracted more and more attention from obstetricians in recent years.The mechanism of fetal growth restriction in preeclampsia patients may be that the superficial infiltration of trophoblast cells and the hypertension vasospasm lead to the hypoperfusion of the uterus and placenta,which makes the surrounding trophoblast cells in a relatively low oxygen state,resulting in the oxidative stress response,which affects the delivery of nutrients to the fetus,resulting in fetal growth restriction.But why is it that,is also a severe preeclampsia,part of fetal growth restriction,and another part of fetal growth restriction,pre-eclampsia and fetal growth restriction what are the potential clinical characteristics,master the clinical features in clinical work for pre-eclampsia and fetal growth restriction mother real-time monitoring,and mother to reduce the occurrence of adverse outcome.This study retrospectively analyzed and studied the clinical data of 133 patients with severe preeclampsia who delivered in the first hospital of jilin university from January 2014 to December 2018.The study group consisted of 67 patients with severe preeclampsia complicated with fetal growth restriction.The control group consisted of 66 patients with severe preeclampsia without fetal growth restriction.The comparative analysis of placental weight,umbilical artery diastolic blood flow,systolic blood pressure,diastolic blood pressure,complications,and mode of termination of pregnancy between FGR and FGR in severe preeclampsia can provide basis for the diagnosis and treatment of FGR in severe preeclampsia,so as to reduce the occurrence of maternal and fetal adverse outcomes.Research data and methods:A retrospective analysis was performed on 133 cases of severe preeclampsia delivered in our hospital from January 2014 to December 2018.The study group consisted of 67 patients with severe preeclampsia with fetal growth restriction.The control group consisted of 66 patients with severe preeclampsia without fetal growth restriction.The general information,pregnancy history,pregnancy complications,maternal laboratory examination and maternal and infant outcomes were analyzed.1.Compare whether the placental weight,which is closely related to fetal growth restriction,is different between the study group and the control group.2.To compare whether there were differences between the study group and the control group in the reversal or disappearance of blood flow in the diastolic period of the umbilical artery.3.The differences of systolic blood pressure,diastolic blood pressure and umbilical artery S/D values between the study group and the control group were compared.4.Compare the incidence and gestational age of the study group and the control group.5.Compare whether there are differences in the incidence of placental abruption between the study group and the control group.6.Compare the incidence of cesarean section due to fetal distress between the study group and the control group.SPSS 24.0 software was used for statistical analysis of the data,and the measurement data were tested for normality.The measurement data of normal distribution were expressed as mean ± standard deviation,the t-test or analysis of variance were used for inter-group comparison,and the non-normal distribution was expressed as median(P25,P75),and the rank-sum test was used for inter-group comparison.Frequency and rate were used to represent the counting data,and chi-square test was used for comparison between groups.If the expected number of data in the four-grid table was less than 5,Fisher’s exact probability method was used for data calculation.P < 0.05 was considered statistically significant.Results:1.The difference in placental weight between the case group and the control group was statistically significant(P<0.05).2.The number of cases of umbilical cord diastolic blood flow reverse or disappeared in IUGR group with severe preeclampsia was higher than that in control group,and the difference was statistically significant(P < 0.05).3.There was no significant difference in systolic blood pressure,diastolic blood pressure and S/D between the case group and the control group(P >0.05).4.There was no statistically significant difference in gestational age between the case group and the control group(P >0.05).5.The probability of placental abruption in the case group and the control group was compared,and the difference in the probability of placental abruption in the two groups was statistically significant(P<0.05).The incidence of placental abruption in severe preeclampsia with IUGR was higher(5.97%)than in the control group(0%).6.The cesarean section rate between the case group and the control group due to fetal distress was compared,and the difference of cesarean section rate between the two groups due to fetal distress was statistically significant(P<0.05).Cesarean section rate of severe preeclampsia with IUGR due to fetal distress was higher(22.39%)than that of the control group(4.55%).Conclusion:1.Preeclampsia with FGR was also associated with placental weight.2.FGR with preeclampsia requires monitoring of fetal umbilical artery blood flow parameters,which can be used for early detection,early diagnosis and early treatment of fetal intrauterine distress,as well as effective intervention for the cause to reduce perinatal mortality.3.Systolic blood pressure,diastolic blood pressure and S/D values had no significant difference between FGR and preeclampsia.4.Preeclampsia with FGR can occur before or after 34 weeks.5.Preeclampsia complicated by FGR was associated with decreased placental perfusion and placental infarction,so there was a trend of increased placental incidence.6.The incidence of fetal distress in the preeclampsia group with FGR was higher than that in the simple preeclampsia group,so close monitoring of fetal condition in the preeclampsia group with FGR was required.The perinatal survival rate can be improved by choosing the right delivery time and delivery method.