Clinical Efficacy Of Low Molecular Weight Heparin In Patients With Failed Repeated Implantation

Objective:To explore the effect of Low-molecular-weight heparin on outcomes of thawed embryo transfer in women with repeated implantation failure(RIF).Methods: From July 2017 to December 2017,80 women under 38 years old,with RIF(ET≥3 times or total 10 high quality embryos the embryos were planted failure)who planned to perform frozen embryo transfer(FET)again were included in the study.There were39 cycles in test group received low-molecular-weight heparin(LMWH)and conventional luteal support from FET day,while 41 cycles in control group only received conventional luteal support.The outcomes of FET were compared between two groups.Results: There were no significant differences between two groups in the age of the patients,BMI,and the number and quality of embryo transplant(P>0.05).There were significant differences in biochemical pregnancy rate(43.59%VS29.27%),clinical pregnancy rate(33.33%VS19.51%)and livebirth rate(25.64% VS 19.51%)between test group and control group(P<0.05).While there were no significant differences in early abortion rate(15.38%VS25.00%),embryo implantation rate(18.42%VS13.84)(P>0.05).Conclusions:LMWH can improve the clinical pregnancy rate,and live birth rate in patients withRIF;however,it can not influence the early abortion rate or embryo implantation rate of women with RIF.