Study On Correlation Between ABO Blood Group And Acute Aortic Syndromes In Qinghai Area

Aim:In this study,we collected the ABO blood group and related risk factors to understand the distribution and correlation of blood group and acute aortic syndrome(AAS).It is clear whether there is a statistical distribution rule between ABO blood group and AAS,which provides further theoretical research basis for the pathogenesis of cardiovascular diseases.Methods:From January 2016 to December 2019,378 AAS patients diagnosed in cardiothoracic and vascular surgery of the affiliated hospital of Qinghai university and 421 routine physical examination people were collected as controls.Through inclusion of exclusion criteria,189 AAS patients and 190 non-AAS patients were finally collected,and relevant clinical data such as ABO blood type,gender,age,BMI index,blood pressure,smoking history,main atherosclerosis,blood lipid level,diabetes history and so on were recorded for statistical analysis.Single factor regression analysis was used to analyze the relationship between each variable factor and AAS,which was significantly incorporated into the multi-factor model,p < 0.05.the difference was statistically significant.Results:1.The study compared and analyzed the general data of the diseased group and the control group,the O group and the non-O group,and the A group and the non-A group.In different blood types,gender,age,BMI index,blood pressure,smoking history,main Atherosclerosis,blood lipid levels,history of diabetes,the results are as follows.1.1 General data: in BMI index,the results of the diseased group were statistically significant compared with the control group [24.47±2.93 vs 22.88±2.73,p<0.01].Compared with the smoking history of the sick group and the control group,the smoking history of the sick group is significantly higher than that of the control group(98(51.9%)vs 30(15.8%)(p < 0.01).Compared with the control group(33(17.5%)vs 12(6.3%)in diabetes history disease group,p < 0.01),the results were statistically significant.The results of Atherosclerosis disease group were significantly different from those of control group(58(30.7%)vs 14(7.4%),p < 0.01).The difference between TG(p<0.05)and acute aortic syndrome is statistically significant,and the level of blood lipid plays an important role in the susceptibility to acute aortic dissection.Hypertension(p<0.01)and hypotension(p<0.01)are statistically significant differences from acute aortic dissection.1.2 Type o group and non-type o group: 106 males(75.7%)and 34 females(24.3%)were found in type o blood,and there were significant differences among different age groups(p<0.05).In addition,among smokers and non-smokers,there were 60 cases of O-type blood,accounting for 41.0% of O-type blood,68 cases of non-O-type blood,accounting for 29.1% of non-O-type blood.The difference between O-type blood and non-O-type blood was statistically significant(p<0.05).1.3 Type a group and non-type a group: the difference between main atherosclerosis,type a blood and non-type a blood is statistically significant(P<0.05).2.AAS and ABO blood types were analyzed by single factor regression.Significant factors were incorporated into the multifactorial model in turn.After adjusting other factors,the results showed that age(p<0.01),atherosclerosis(p<0.01),diastolic pressure(p<0.01),TG(p<0.05)and O-type blood group(p<0.05)were risk factors of AAS.BMI(p<0.01),blood pressure(p<0.01),smoking history(p<0.01)and diabetes history(p<0.05)are independent risk factors for acute aortic syndrome.Conclusions:According to the study on the distribution of ABO blood group and acute aortic syndrome,people with O blood group may have higher risk of morbidity than people with other blood groups.Obesity,higher systolic blood pressure,smoking history and diabetes history are independent risk factors in the pathogenesis of AAS,and the above risk factors may play a mediating role in the pathogenesis of blood type and AAS diseases.