Multivariate Analysis Of Low Anterior Resection Syndrome Of 230 Postoperative Patients With Rectal Cancer

Objective:To analyse the postoperative defecation function in 230 cases of rectal cancer,and study the risk factors of the low anterior resection syndrome(LARS).Methods:230 cases of low rectal cancer who underwent the low anterior resection in Shanxi Provincial People’s Hospital during from January 2013 to December 2017 were selected,and all of them followed the TME principle.During this period,telephone follow-up,face-to-face follow-up and other methods were used for evaluating the defecation function of the subjects.Based on the severity of the patient of LARS,we tried to find out the difference of several clinical factors between the group of above lowgrade LARS and the group of asymptomatic LARS.Results:Out of 230 patients,patients with above low-grade LARS for 126 cases(54.8%),and104 patients with asymptomatic LARS(45.2%).It was demonstrated that the difference in sexes(P < 0.05),N stage(P < 0.05),tumor location(P < 0.05),preventive colostomy(P < 0.05),and the presence of the ileum anastomotic leakage(P < 0.05)was statistically significant;Results from multivariate analyses shown that the difference in gender(OR =2.301,95% CI: 1.239,4.275,P < 0.05)、 tumor location(OR = 0.410,95% CI: 0.410,0.410,P < 0.05)and the presence of anastomotic leakage(OR=29.289,95%CI: 1.045,82.533,P < 0.05)was statistically significant.According to the distance from the loweredge of the tumor to the anal margin,the low tumors were divided into two groups: low(3-5 cm)and ultra low(<3 cm).The χ2 test showed no statistical significance(P>0.05).Conclusion:The incidence of the LARS in postoperative patients with rectal cancer is high.The severity of the LARS is affected by N stage and preventive colostomy.The female,low tumor and anastomotic leakage are independent risk factors.