Clinical Features Of Antrochoanal Polyps In Children And Expression Of Cytokines

Objective This study is to investigate differences of clinical features and expressions of IL-5 AND Eotaxin in nasal polyp tissues between antrochoanal polyps(ACPs)and Chronic rhinosinusitis with nasal polyps(CRSw NP)in children.To explore the clinical Features and cytokine expression of ACPs in children.Methods Children patients(≤14 years old)with choanal polyps who received operations in the First Affiliated Hospital of Fujian Medical University from 2013-2018 were collected.a total 24 ACPs cases and 35 CRSw NP cases were collected.Medical data of ACPs and CRSw NP were reviewed.Clinical features,pathological characteristics,operation mode and recurrence rate of ACPs and CRSw NP were compared.Additionally,post-operation nasal polyp tissues were collected and processed into slices for statistical analysis of number of Eotaxin.Next,expressions of IL-5 and Eotaxin in pathological tissues of ACPs and CRSw NP were analyzed qualitatively by using immmunohistochemical technique,and then quantized for statistical analysis.Results 1)In children patients,ACPs are mainly observed at one side(24/24cases),the left side is more common than the right side(14:10),whereas CRSw NP mainly develop at two sides(24/35).ACPs are mainly manifested by frequent nasal obstruction(100%)and rhinorrhea(91.7%)in clinically.Besides,ACPs could be excised completely by nasal endoscopic surgery.Nasal endoscopic surgery is safe and effective(91.7%)and has a low recurrence rate(8.3%).2)Under the optical microscope(×400)field of view,the eosinophil count in children’s ACPs tissues was 3.42±0.71,and the eosinophil count in children’s CRSw NP tissues was 18.13±2.13,the difference was statistically significant(P<0.05).3)The IL-5AOD in children’s ACPs tissues was 0.338±0.066,and the IL-5AOD in children’s CRSw NP tissues was 0.68±0.131.The difference was statistically significant(P<0.05).4)The Eotaxin AOD in children’s ACPs tissues was 0.270±0.078,and the Eotaxin AOD in children’s CRSw NP tissues was 0.464±0.091.The difference was statistically significant(P<0.05).Conclusions 1)Frequent nasal obstruction and rhinorrhoea are common symptoms of ACPs in children patients.In particular,nasal obstruction at one side shall be suspected of possibility of ACPs.In this case,paranasal sinus CT examination shall be performed,which is conducive to explicit diagnosis.FESS operation is the first choice to treat ACPs of children patients.The key of operation is to determine the position of root and eliminate the root and polyps tissues completely.2)The pathogenesis centered at Eotaxin might play an important role in the pathogenesis of ACPs in children patients.This reflects that allergic factors may not be the key cause of ACPs in children patients.ACPs and CRSw NP in children patients might have different pathogeneses.