Clinical Study On Neonatal Respiratory Syncytial Virus Infection

Objective: Exploring the clinical characteristics of severe respiratory syncytial virus infection in newborns,and to analyze the related risk factors.Methods:(1)To analyze the clinical data of 401 cases of neonatal RSV pneumonia,which were diagnosed from January 2016 to December 2017 in the neonatology department of Children’s Hospital of Chongqing Medical University.(2)In accordance with the diagnostic criteria of severe pneumonia of Practical Pediatrics of Zhu Futang(Edition 8)[1],dividing it into two groups called severe infection group and non-severe infection group.(3)To compare the clinical data of severe infection and non-severe infection in newborn infants with RSV,and the univariate and multivariate logistic regression analysis were performed to analyze the risk factors of severe RSV infection using SPSS20.0 software.Results:(1)There were significant differences in jaundice(P=0.001)as well as vomiting and choking milk(P=0.0.021)between neonatal RSV severe infection group and neonatal RSV non-severe infection group.(2)Univariate analysis of neonatal RSV severe infection showed that there were significant differences in premature infants,birth weight,breastfeeding,winter onset,the age of infection and congenital heart disease.(3)Multivariate logistic regression analysis showed that congenital heart disease was an independent risk factor for the neonatal RSV pneumonia developing into severe infection(OR=2.534,95% CI:1.271~5.049,P < 0.05),and breastfeeding could reduce the risk of severe infection(OR=0.574,95%CI:0.332~0.911,P < 0.05).Conclusion: Breastfeeding is a protective factor for severe infection of neonatal RSV pneumonia,while congenital heart disease is a risk factor for severe infection of neonatal RSV pneumonia.