3D Printed Drug-loaded Stent For The Treatment Of Breast Cancer

Cancer is a serious threat to human health and there is no fully effective treatment strategy.Researchers from all over the world have devoted a lot of manpower and material resources to exploring more effective cancer treatments and advanced diagnostic techniques,but still have not achieved the desired therapeutic effects.More and more researchers are turning to research on new drug delivery methods,including local tumor treatment,immunotherapy,and targeted therapy.In the field of topical treatment,drug-loaded in vivo grafts have attracted widespread attention in cancer therapy due to their advantages in accurately delivering drugs to tumor tissues.Compared with the traditional method of administration,it greatly reduces the frequency of administration,and can enrich relatively high concentrations of drugs at the tumor site,avoiding systemic side effects.This study developed a new precision local therapeutic drug delivery device: drug sustained release of polylactic acid-glycolic acid copolymer(PLGA)loaded with doxorubicin(DOX)and cisplatin(CDDP)prepared by 3D printing technology.By combining synergistic chemotherapy strategies,it was shown to inhibit breast tumor growth in mice with orthotopic breast cancer and to reduce distal lung metastasis.In vitro and in vivo experiments have shown that this drug-loaded stent has a better anti-tumor effect than conventional drug delivery methods.This study is expected to be applied to the clinical load of a variety of drugs,and is conducive to the coordinated treatment of drug-resistant tumors,and has great development prospects in cancer treatment.