| Objective Evaluation of HPV infection and its types differences between Han and Mongolian women in the same area of China.And in the same area of China the differences of HPV infection in different cervical lesions between Han and Mongolian women.To explore the dynamic changes of HPV infection between Han and Mongolian during the cohort follow-up.In order to provide a strong basis for cervical cancer screening and vaccination in different nationalities in China.Methods In 2017,a total of 2,398 eligible subjects were recruited for the cervical cancer campaign in Etuoke banner,Ordos City,Inner Mongolia Autonomous Region.Two samples with vaginal secretions were collected from each subject by self sampling and detected them by PCR HPV detection technology(no typing)and care HPV detection technology respectively.PCR HPV typing and colposcopy were performed in the patients with any of the above two HPV test results.If the colposcopy shows that the cervical squamous column junction is completely visible,take biopsy at the abnormal place.if the cervical squamous column junction is not completely visible / completely invisible,perform endocervical curettage and take biopsy at the abnormal place.In July 2019,the above recruited population will be recalled and the above screening process will be repeated.The final diagnosis was based on pathological diagnosis.Results 1.In 2017,2,398 people were admitted,including 1,321 Hans and 1,077 Mongols.Women living in Etuoke Banner are generally less educated(77.50%)and the majority of they are farmers(66.50%).Nearly half had heard of cervical cancer(41.60%),but only a minority had been screened(27.90%),a result that was partly due to poor publicity(HPV awareness was only 6.40%).2.In this study,the total prevalence rate of cervical lesions in women in Etuoke banner was 2.16%,the prevalence of Han nationality was 1.49%;the prevalence of Mongolian nationality was 2.97%,and the difference was statistically sgnificant(P < 0.05).3.When the pathological grade is cin1,the top five dominant types of HPV infection in the Han nationality are HPV 51,53,16,52 and 59;The highest HPV infection rate in Mongolia is hpv53,followed by hpv56,52,16 and 18.The difference of HPV 56 infection rate was statistically significant(c 2 = 5.255,P < 0.05).When the pathological grade was Cin2 +,HPV16 was the first in Han and Mongolian,followed by HPV33 in Han,and it was the third in Mongolian,HPV18 ranked the second in Mongolian,but not in Han.The difference is statistically significant(c2 = 4.364,P < 0.05),while in Han,the infection rate of hpv68 was 33.33%,significantly higher than that in Mongolian(10.00%),the difference was statistically significant(c2 = 5.605,P < 0.05).4.The multiple infection rate of Cin2 + patients was 81.30%,significantly higher than that of cin1 patients,and the multiple infection rate was the main one(66.70%);the infection rate of Cin2 + patients with HPV16 was 56.30%,significantly higher than that of cin1 patients,the difference was statistically significant(P < 0.05).5.The infection rate of HPV types covered by the three vaccines was statistically significant(P < 0.05)when the pathology was cin1.In Cin2 +population,the infection rate of bivalent vaccine group was 81.25%,that of bivalent vaccine group was 100%,and that of bivalent HPV vaccine group was the same as that of bivalent HPV vaccine group.6.The rates of HPV infection in 2017 and 2019 were(17.3% and 24.7),respectively,and in 2017 and 2019,the HPV infection rate of Mongolian was 23.0 and 31.5respectively,in 2017 and 2019,there was a significant difference in HPV infection rate between Han and Mongolian(P < 0.05).In this year,the difference of HPV infection rate between Han and Mongolian was statistically significant(P >0.05).In 2017 and 2019,the top three HPV types of Han and Mongolian were Han,52,58 and 68.By 2019,HPV16 exceeded all types and became the highest HPV type of Han,but the difference was not statistically significant.Mongolian 53,52 and 68 have a relatively flat change,and the third place of knowledge is replaced by HPV56.Conclusion 1.Women’s health awareness in Etuoke is relatively weak,which is largely due to poor publicity.2.The prevalence of Cin2 + is high in this area,and it is mainly Mongolian,which may be related to the screening of farmers and Mongolians are more susceptible to HPV.3.Among CIN1 patients,the Han and Mongols HPV infection types were significantly different.HPV16 was the main type in Cin2 + population..It should be noted that HPV33 and HPV18 are of secondary importance in Han and Mongols patients respectively.This may indicate that the occurrence of cervical cancer in this region is closely related to the infection of these three types of HPV,these three racial high-risk HPV types can be appropriately addressed more aggressively.4.Compared with CIN1,CIN2 is more obvious for multiple HPV infections,which may indicate that multiple HPV infections play a promoting role in the development of the disease,but more trials are needed to confirm this.The majority of the patients were infected with HPV16,which further demonstrated the harm of HPV16 in the development of the disease.5.According to the infection coverage of different HPV vaccines,bivalent vaccine can be used to prevent cervical cancer at present,but the bivalent vaccine is the best choice when the nine-valent vaccine is available.6.The rate of HPV infection in Mongolian is higher than that in Han.Even if there is no special intervention from outside,the dominant types of HPV in the same nation will fluctuate at different times,but the infection rate of HPV will not change much.The main types of HPV infection are not the same in different ethnic groups,but HPV52 type is always in the first two,and it is also one of the main types of cervical diseases.Therefore,more attention should be paid to this type in future screening and vaccination. |
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