Correlation Of Clinical,Pathological And Imaging Features Of Cystic Lung Cancer

Objective:To explore the correlation between the imaging signs and the clinical and pathological features of cystic lung cancer,and to deepen the understanding of these lesions.Methods:Confirmed by surgery or biopsy in our hospital were retrospectively analyzed CT performance for cystic cavity class medical record of 104 cases of lung cancer,according to the presence of ground glass density window is divided into lung ground glass density and of ground glass density group,according to the pathological type was divided into adenocarcinoma and adenocarcinoma group,according to the EGFR mutation genetic tests are divided into groups with the mutation,compare the clinical,pathological and imaging information.The measurement data were expressed as mean ± standard deviation,and independent sample T test or mann-whitney U test were used for inter-group comparison.The counting data were expressed by frequency and percentage,and the comparison between groups was analyzed by chi-square test or Fisher’s exact probability method,and P<0.05 was statistically significant.Results:1.There were 87 cases of adenocarcinoma and 17 cases of non-adenocarcinoma.Adenocarcinoma was significantly associated with women,no history of smoking,irregular morphology of the lesion,and bronchial passage signs(P<0.05).There were 66 cases of EGFR gene examination,41 cases of gene mutation,and 25 cases of no mutation.EGFR mutations are significantly associated with women,no smoking history,vascular bundle sign and wall nodules(P<0.05).The cystic cavity was visible in 14 cases under light microscopy: 9 cases had walls of tumors and necrotic tissue,and 5 cases had walls of fibrous tissue or bronchial epithelium.2.> 50% of the CT findings are irregular morphology,blurred tumor-lung interface,lobulation sign,pleural pull sign,vascular bundle sign,single capsule,regular shape of capsule cavity,uneven thickening of capsule wall,and smooth inner wall,Wall nodules and internal separation.Density grouping compares 57 cases in the non-ground glass density group and 47 cases in the ground glass density group.The largest diameter of the cystic cavity with ground glass density is smaller,and glitches and wall nodules are rare.It is significantly related to adenocarcinoma,EGFR mutation,blurred tumor-lung interface,and intravesical blood vessel passage(P<0.05).3.Significant changes occurred in 73.3% of the follow-up lesions,with increased solid components or reduced cystic cavity.Conclusions: The formation mechanism of cystic cavity lung cancer may be related to the formation of check valve structure and cystic necrosis.Clinical,pathological and CT signs have certain correlation,and follow-up is helpful for diagnosis.