Estimated Value Of Serum Galectin-3 For The Risk Stratification Of Non ST-elevation Acute Coronary Syndrome Patients

Objective: Non-ST-segment elevation acute coronary syndrome(NSTEACS)is one of the most dangerous types of coronary heart disease,which has the features of acute attack and poor prognosis.As an inflammatory factor,galectin-3(Gal-3)has been implicated in the pathologic process of atherosclerosis.The global registry of acute coronary events(GRACE)risk score is recognized as the most effective scoring system for the risk and prognosis of NSTE-ACS.GRACE scoring involves so many factors that it is not easy to get results quickly.Therefore,it’s urgent to find a simple and cost-effective biomarker to evaluate the risk stratification in NSTE-ACS.However,the relationship between Gal-3 and GRACE score is unknown in NSTE-ACS patients.The purpose of this study was to analyze the Gal-3 level in NSTE-ACS patients and its correlation with GRACE score,to explore whether Gal-3 can be used as an independent predictor of risk stratification in NSTE-ACS patients,and to assess the value of Gal-3 for the risk stratification in NSTE-ACS patients.Methods: 1 A total of 95 patients diagnosed as NSTE-ACS by coronary angiography at the Second Hospital of Hebei Medical University from February 2019 to December 2019 were selected.As control group,14 healthy volunteers in the same period were included.We recorded clinical data and laboratory indicators in detail.2 NSTE-ACS patients were given GRACE risk score and further divided into three groups,as low-risk group(≤108 points),intermediate-risk group(109-140 points)and high risk group(>140 points).3 Peripheral venous blood was collected from all subjects.Gal-3 level was measured by enzyme linked immunosorbent assay.Results: 1.There were no statistically significant differences in age,gender,heart rate,diabetes history,smoking history and drinking history between the control group,and NSTE-ACS group.The body mass index,systolic blood pressure,diastolic blood pressure and history of hypertension in the NSTE-ACS group were higher than those in the control group(P<0.05).2.No statistical difference was found in total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C)and creatinine(Cr)between the control group and NSTE-ACS group.Compared with the control group,the levels of fasting blood glucose(FBG),glycated hemoglobin(GHB),low density lipoprotein cholesterol(LDL-C),and cardiac troponin I(c Tn I)in NSTE-ACS group was higher(P<0.05).3.There were no statistically significant differences in gender,body mass index,systolic blood pressure,diastolic blood pressure and history of hypertension,systolic blood pressure,diastolic blood pressure and history of hypertension of patients in GRACE low-risk,intermediate-risk and high-risk groups.The age in GRACE high-risk groups was higher than other groups.The heart rate in GRACE intermediate-risk group was higher than low-risk group.4.No statistical difference was found in FBG,GHB,TC,TG,LDL-C,HDL-C,Cr and c Tn I of patients in GRACE low-risk,intermediate-risk and high-risk groups.5.Plasma Gal-3 level in NSTE-ACS group was higher than the control group(P<0.05).6.The concentration of Gal-3 in the high-risk group was higher than that of the low-risk group(P<0.05).There was no significant difference between the medium risk group and other groups.7.Gal-3 level was positively corrected with GRACE score(r=0.491,P<0.001).8.Univariate correlation analysis showed that GRACE score was positively correlated with smoking history,age,Gal-3 level,heart rate,c Tn I and drinking history in NSTE-ACS patients(r= 0.679,0.564,0.491,0.329,0.290,0.206,P<0.05).Gal-3 was an independent predictor of risk stratification in NSTE-ACS patients by multiple liner regression analysis.9.The ROC curve analysis showed the area under the curve of Gal-3 was 0.819(95% CI 0.721-0.917)for high-risk patients with NSTE-ACS,the best cut-off point was 40.42 pg/ml(P<0.05).Conclusion: 1.The Gal-3 level of patients with NSTE-ACS was significantly higher than that of the control group,suggesting that Gal-3 may be involved in plaque formation and reflect plaque instability.2.Gal-3 level was significantly increased in the high-risk patients with NSTE-ACS.Gal-3 level was positively correlated with GRACE score.Gal-3 could be used as an independent predictor of risk stratification in NSTE-ACS patients.Serum Gal-3 level may have a certain predictive value for high-risk patients with NSTE-ACS.