| Objective: To explore the theoretical basis and clinical efficacy of tonifying kidney and invigorating spleen,activating blood circulation and soothing liver in the treatment of chronic kidney disease(non-dialysis).Methods: 1.Treatment research: the treatment is sorted out and summarized through literature research,theoretical discussion and clinical experience summary.2.Clinical study: 97 patients with chronic kidney disease(non-dialysis)who met the inclusion criteria were randomly divided into treatment group(n = 50)and control group(n = 47).The control group was treated with western medicine,and the treatment group was treated with the methods of tonifying kidney and invigorating spleen,activating blood circulation and soothing the liver on the basis of western medicine,and the curative effect was observed for 12 weeks.In the course of treatment,TCM clinical symptoms,TCM syndrome scores and related laboratory indexes such as serum creatinine(Scr),urea nitrogen(Bun),glomerular filtration rate(e GFR),blood routine,liver function and electrolytes were recorded before and after treatment.Through the data collation,the use of spss25.0 statistical software to analyze the data.Result: 1.Research on treatment: traditional Chinese medicine believes that chronic kidney disease is caused by various pathogenic factors acting on the body,resulting in deficiency of Zang-fu organs and imbalance of qi,blood,yin and yang.The root of the disease lies in the deficiency of kidney qi,which can not promote the movement of blood and produce blood stasis.Blood stasis runs through the whole development process of the disease,which is not only the pathological product of the disease,but also an important independent factor to accelerate the progress of the disease.The filling of essence qi in the kidney depends on the fine cultivation of the acquired spleen.When treating diseases,tonifying the kidney should be taken into account at the same time.At the same time,the long course of the disease,poor prognosis,high treatment costs and other factors make the psychological burden of patients,so it is easy to produce negative emotions such as depression and anxiety,which is not good for the prognosis of the disease,so we should pay attention to soothing the liver in clinical treatment.therefore,in the treatment of chronic kidney disease,tonifying the kidney and invigorating the spleen,activating blood circulation and soothing the liver are the treatment rules.2.Clinical study:(1)Total efficacy: the total effective rate of the treatment group was 76%,while that of the control group was 63%.The comparison between the two groups showed that the curative effect of the treatment group was better than that of the control group(P<0.05).(2)Clinical symptoms: compared with the control group,the treatment group could significantly improve the symptoms such as tiredness,lack of appetite,sore waist and knees,good rest,depression,apathy,irritability and irritability(P<0.05).There was no significant difference in the total scores of TCM symptoms and clinical symptoms such as low back pain,limb numbness,skin nail error,long nocturia and false stool(P>0.05).(3)Laboratory indexes: the treatment group could reduce creatinine and urea nitrogen and increase glomerular filtration rate(P<0.05).Compared with the control group,creatinine and glomerular filtration rate had no significant difference(P>0.05).The treatment group was superior to the control group in reducing urea nitrogen(P<0.05),but there was no significant difference in albumin between the two groups(P>0.05).Compared with the two groups of total carbon dioxide,red blood cells,hemoglobin,the treatment group was better than the control group(P<0.05),the difference was statistically significant.There was no significant difference in serum potassium,alanine aminotransferase and aspartate aminotransferase between the two groups before and after treatment(P >0.05).Conclusion: 1、Chronic kidney disease(non-dialysis)causes patients to have a great psychological burden because that the characteristics of this disease such as long course of disease,easy to relapse,poor prognosis,fear of dialysis.which will accelerate renal progression.Using the method of invigorating kidney and spleen,invigorating blood,soothing the liver in the treatment of the chronic kidney disease(non-dialysis),which can improve the patient’s clinical symptoms,reduce Scr,Bun,increase e GFR.Protecting kidney function,delaying kidney function progress,which has a better curative effect.2、For patients with chronic kidney disease(non-dialysis),It is safe and feasible to use the methods of invigorating kidney and spleen,invigorating blood,soothing the liver to treat the disease when their blood pressure,blood sugar,electrolyte disorder and acidosis are under control.However,during the treatment,regular review should be conducted and pay close attention to the patient’s electrolyte and other relevant laboratory indicators. |
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