A Randomized,controlled,multicenter Clinical Study Of "Modified Sedentary Wuqinxi" In Patients With Mechanic Al Ventilation In ICU

Research Background:Mechanical ventilation is a powerful tool for the treat ment of various critical and critical diseases,and the prevention of various co mplications and adverse outcomes of mechanical ventilation in ICU is the focu s and difficulty of clinical work.Early activity is the key to improve the com plications and outcome index of mechanical ventilation in ICU."Modified sede ntary Wuqinxi"has shown its unique advantages as an auxiliary rehabilitation t herapy.Research Objective:For ICU mechanical ventilation in patients with higher in cidence of complications,high mortality and hospitalization costs higher clinical problem,this study applied the"Modified sedentary Wuqinxi"to the severe p atients with mechanical ventilation,and observed its effect on the incidence of complications related to mechanical ventilation,mechanical ventilation time,len gth of ICU stay,hospitalization cost.Based on"Modified sedentary Wuqinxi",it provides a reliable,simple and feasible auxiliary rehabilitation treatment sche me for ICU patients with mechanical ventilation.Research Methods:This study is a multi-center,randomized,single blind,para llel trial,which was completed in three centers:affiliated hospital of chengdu university of traditional Chinese medicine,affiliated hospital of chengdu univers ity,and leshan hospital of traditional Chinese medicine.Qualified patients were screened and divided into experimental group and control group.Patients in bo th groups were given standard comprehensive treatment of western medicine（in cluding mechanical ventilation）and routine care in ICU.On the basis of basic treatment,experimental group was given"Modified sedentary Wuqinxi":each group was given Huxi six times,three groups were given at 09:00;Xiongxi,t hree groups,each group was given six times;each group was given at 13:00;Niaoxi six times,three groups were given at 15:00;Luxi,three groups,each g roup was given six times at 19:00.The APACHE II score,duration of mechani cal ventilation,average length of stay in ICU,and complication rate of mechan ical ventilation were compared between the two groups.The final observation data were analyzed by SPSS26.0 statistical software.Research Results:A total of 73 patients were included in this study,including35 in the experimental group and control group,and 3 in the control group（2 in the experimental group and 1 in the control group）.There was no signifi cant difference（P>0.05）between the two groups in age,sex composition ratio,ApacheⅡscore,disease composition ratio,basic vital signs（HR,R,BP）,respi ratory function index（PO₂,PCO₂,PO₂/Fi O₂）and other baseline data.The median number of days of mechanical ventilation（IQR）was 7（3.4,13）days in the experimental group and 11（7,16）days in the control group,sh owing a significant difference（P=0.036,P<0.05）.The median length of stay in ICU（IQR）was 12（8,19）days in the experimental group and 15（11,22）days in the control group,with statistical difference（P=0.044,P<0.05）.The average hospitalization cost of the two groups was significantly lower in the experiment al group than in the control group（95452.81±63872.94 yuan vs 128114.58±64765.67 yuan,P=0.037）.There was no significant difference in MRC score between the two groups before treatment（P>0.05）;MRC score of the two groups after treatment was higher than that before treatment,and the experimental group was higher than that of the control group（P<0.05）.There were significant differences in the inc idence of delirium in adverse events between the experimental group and the c ontrol group（P<0.05）,and the incidence of delirium in the experimental group was significantly lower than that in the control group.Conclusion:In conclusion,the"Modified sedentary Wuqinxi"is safe and effect ive in the treatment of patients with mechanical ventilation in ICU,which can shorten the duration of mechanical ventilation and the length of stay in ICU,r educe hospitalization costs,reduce the incidence of mechanical ventilation comp lications,and thus improve the clinical efficacy and prognosis of patients with mechanical ventilation in ICU.