Study On The Clinical Effect Of Xinshuaining On Patients With Chronic Heart Failure And Anxiety And Depression Based On "Simultaneously Treatment On Psycho-cardiology"

Objective: This study combined with the tutor’s many years of clinical work experience,taked the invigorating heart and spleen as the main therapy,and using Xinshuaining to treat patients with chronic heart failure(CHF)combined with anxiety and depression(syndrome of deficiency of both heart and spleen),did a preliminary exploration of its impact on the CHF with anxiety and depression patients’ clinical symptoms before and after treatment,anxiety and depression status,traditional Chinese medicine(TCM)syndromes,etc.Evaluated the clinical efficacy and safety of Xinshuaining in CHF patients with anxiety and depression.Methods: A total of 100 CHF patients with anxiety and depression were selected for consultation in cardiovascularmedicine at connected hospital of Chengdu University of Traditional Chinese Medicine from November 2018 to October 2019,and were randomly divided into observation group(50 cases)and control group(50 cases)in two groups.The control group only according to the guidelines to give formal anti-heart failure treatment plan,the observation group on the basis of the control group to add Xinshuaining Chinese decoction,3 times a day,each 100 ml,both groups of patients treatment course is 4 weeks.Observed and recorded the changes of clinical symptoms before and after treatment score,heart function parameters,anxiety and depression self-assessment scale score,NT-pro BNP,and TCM symptoms score,etc.At the same time,did routine detection of adverse reactions indicators and observe the safety of drugs.Results: Prior to treatment,gender,age,course of disease,basic disease,cardiac function class,TCM symptoms,Lee’s heart failure score,NT-pro BNP,left ventricular blood score and anxiety depression score between the two groups were not statistically significant(P>0.05),so the study was comparable.After 4 weeks of treatment,both groups showed cases of declining or missing and discontinuing,and a total of 96 subjects completed clinical observation.In terms of anxiety and depression scores,the SAS and SDS scores decreased in both groups after intervention,while the SAS and SDS scores in the observation group were significantly lower than those of the control group after intervention,with the difference was statistically significant(P<0.05),and compared with the pre-intervention,the difference was statistically significant(P<0.05).In terms of TCM symptoms,the apparent eff The Monitoring Group and the Control Group were able to:compared,the efficacy of individual TCM symptom after treatment was compared,cyanosis:the observation group and the control group had significant differences(P<0.01).Heart palpitations,chest tightness,shortness of breath,fatigue,insomnia,puffiness,less urine:the observation group and the control group had significant differences(P<0.05).In terms of the overall efficacy of TCM symptoms:compared with the control group,the total efficiency of the observation group was 95.83%,the control group was 81.25%,the observation group showed efficiency of 50.00%,the control group showed efficiency of 25.00%,better than the control group.According to Ridit analysis,the apparent efficiency of the two groups P=0.011<0.01,showed a significant differences in efficiency.Compared to the control group in terms of the total efficacy of TCM symptoms in the two groups,the overall performance of the observation team was 95.83%,the control group was 81.25%,the observation group showed efficiency of 50.00%,the control group showed efficiency of 25.00%,which was better than the control group.According to Ridit analysis,the apparent efficiency of the two groups,P<0.01,showed a significant difference in efficiency.The comparison of total TCM symptoms scores showed that the clinical symptoms of both groups improved significantly,while the observation group showed that the efficiency was better than that of the control group.Comparison of cardiodynamic efficacy in two groups of patients after treatment:89.6%of the total efficiency of the observation group,87.5%of the control group,the observation group was better than the control group(P<0.01).In terms of BNP before and after treatment,the levels of BNP in the two groups of patients decreased significantly after treatment,and the observation group was clearly better than the control group.In terms of comparison of echocardiographic detection indicators,there were significant differences in the LVEDD(mm),LVEF(%),and LVESD(cm)between the observation group and the control group before and after treatment(P<0.05).Conclusion: Xinshuaining has good clinical efficacy in improving the clinical symptoms,signs and anxiety and depression status in patients with chronic heart failure and anxiety and depression,and there are no obvious toxic side effects,and the safety is good,which is worthy of further application and popularization in clinical practice.