Meta-analysis On The Correlation Between Risk Factors Of Stroke And Post-stroke Depression

Objectives The correlation between the risk factors of stroke and the incidence of poststroke depression(PSD)was systematically evaluated,and the relevant factors affecting the incidence of PSD were discussed,so as to provide an evidence-based basis for the early prevention of PSD.Methods Literature retrieval was carried out by computer,and "post-stroke depression","hypertension","diabetes","coronary heart disease" and "dyslipidemia" were used as the main search words to search Chinese databases such as CNKI,CQVIP database and WANFANG data.English databases such as Cochrane library,Web of Science,EMBASE and PUBMED were retrieved from January 1,1990 to June 30,2019 with "post-stroke depression","hypertension","diabetes","coronary heart disease" and "dyslipidemia" as the main English search words.Choose Newcastle card-Ottawa scale(NOS scale)quality of literature evaluation,USES the Review Manager 5.3 the Meta analysis of the literature of into,calculating odds ratio(OR value),the calculation results by using the fixed effect model and random effect model do sensitivity analysis,using the OR values and 95% confidence interval(95% CI)to evaluate different stroke risk factors and incidence of PSD correlation,into literature publication bias test using the funnel figure,using Stata 15.1 software for sensitivity analysis.Results 1 In this meta-analysis,34 case-control studies on the correlation between hypertension and PSD were included,among which 6913 patients had a history of hypertension and 3045 patients had no history of hypertension,with a combined OR value of 2.07(95%CI: 1.55-2.77).2 In this meta-analysis,29 case-control studies on the correlation between diabetes and PSD were included,of which 2077 patients had a history of diabetes and 6736 patients had no history of diabetes,with a combined OR value of 1.50(95%CI: 1.19-1.89).3 Eighteen case-control studies on the correlation between coronary heart disease and PSD were included in this meta-analysis,of which 2029 patients had a history of coronary heart disease and 5323 patients had no history of coronary heart disease,with a combined OR value of 1.18(95%CI: 1.06-1.32).4 Fourteen case-control studies on the correlation between dyslipidemia and PSD were included in this meta-analysis,among which 3455 patients had a history of dyslipidemia and 3754 patients had no history of dyslipidemia,with a combined OR value of 1.56(95%CI: 1.14-2.14).5 Subgroup analysis showed that both the Hamilton scale group(HAMD group)and other scale groups had an impact on the correlation between hypertension and PSD(OR value was 2.89,P < 0.00001;OR value was 1.49,P = 0.04),HAMD group had an impact on the correlation between diabetes and PSD(OR value was 1.98,P < 0.00001),other groups had an impact on the correlation between coronary heart disease and PSD(OR value was 1.20,P = 0.01),and other groups had an impact on the correlation between dyslipidemia and PSD(OR value was 1.54,P = 0.03).6 Sensitivity analysis results showed that the combined results of the four meta-analyses were stable.7 Funnel plot results showed that none of the four metaanalyses included any significant publication bias.Conclusions Among the risk factors for stroke,hypertension,diabetes,coronary heart disease and dyslipidemia are all related to the onset of PSD and are all risk factors for PSD.Therefore,in clinical work,early intervention of PSD can be carried out for stroke patients with the above diseases,so as to improve the prognosis and quality of life of patients.Figure 18;Table 1;Reference 148...