Relationship Between Fasting Blood Glucose And Newonset Gallstone Disease

Objectives To explore the relationship between fasting blood glucose(FBG)and the risk of cholelithiasis.Methods A total of 87513 participants from Kailuan study who were performed in fasting blood glucose,liver and gallbladder ultrasonography detection were selected.According to the results of the blood glucose test,the subjects were divided into normal blood glucose group(n=73456);fasting glucose impaired group(n=7165)and diabetic group(n=6892).Log-rank test was used to compare the cumulative incidence of cholelithiasis in different groups and the COX proportional hazard model to analyze the risk ratio and 95% confidence interval of different groups for new cholelithiasis.A stratified analysis was used to compare the risk ratio and 95% confidence interval for cholelithiasis in different groups with different gender,serum lipid levels and BMI index.Results During a median of 6.89 years of follow-up,Among 87,513 cases,2876 new cases of cholelithiasis have happened.The cumulative incidence of cholelithiasis in the normal blood glucose group,fasting glucose impaired group and diabetic group were 10.91%,12.17%,and 18.86%,respectively.There were statistically significant differences of the cumulative incidence of cholelithiasis in the three groups(P<0.05).In the COX proportional hazard model analysis,after adjusting for other factors continuously,the risk of new cholelithiasis in the fasting glucose group was 0.97(95%CI 0.85～1.11),and the risk of new cholelithiasis in the diabetic group was 1.15(95%CI 1.01～1.30).Comparing with the normal blood glucose group.Stratified analysis reveals that Diabetes is a risk factor for new～onset cholelithiasis among the population of male 1.16(95%CI 1.01～1.33),normal blood lipids 1.22(95%CI 1.01～1.49)and BMI overweight 1.16(95%CI 1.01～1.35).Conclusions Increased fasting blood glucose can increase the risk of cholelithiasis.Diabetes is an independent risk factor for cholelithiasis in men,normal blood lipids,and overweight BMI.Figure 1;Table 9;Reference 178...