Expression Of TLR4,IL-6 And IL-35 In Adenoid Tissues Of Children With Adenoidal Hypertrophy

Objective: The expressions of Toll-like receptor 4(TLR4),Interleukin-6(IL-6)and Interleukin-35(IL-35)in the adenoid tissues of children with different diseases were detected by immunohistochemical method,and the theoretical basis for non-surgical treatment of adenoid hypertrophy was discussed.Methods:According to the cause of the disease,adenoid tissue samples from children with adenoidal hypertrophy are divided into three groups: simple adenoidal hypertrophy(simple hypertrophy group),combined with repeated respiratory infections(repeated respiratory infection group)and combined allergic rhinitis,Allergic disease group(allergic disease group)such as bronchial asthma,each group was 39 cases,57 cases,63 cases.The expressions of TLR4,IL-6 and IL-35 in different adenoid tissues were detected by immunohistochemistry.The differences in expression between the groups were compared.Result:1.The positive expressions of TLR4: There were significant differences in the expression levels among the three groups: simple hypertrophy group,recurrent respiratory tract infection group and allergic disease group,and the difference was statistically significant(F=11.39 P<0.01).Compared with the simple hypertrophy group,the expressions in the allergy group and recurrent respiratory infection group were significantly increased,and the difference was statistically significant(P<0.01);the repeated respiratory tract compared with the allergy disease group,the expressions in allergic disease group was significantly higher in the recurrent respiratory infected group,and the difference was statistically significant(P<0.05).2.The positive expressions of IL-6: There were significant differences in the expression levels among the three groups: simple hypertrophy group,recurrent respiratory tract infection infection group and allergic disease group,and the difference was statistically significant(F=13.72 P<0.01).Compared with the simple hypertrophy group,the expressions in recurrent respiratory infection group and the allergic disease group were significantly increased,and the difference was statistically significant(P<0.01);Compared with the allergic rhinitis group,the expression in allergic disase group was significantly higher in the recurrent respiratory infection group,and the difference was statistically significant(P<0.05).3.The positive expressions of IL-35:There were significant differences in the expression levels among the three groups: simple hypertrophy group,recurrent respiratory tract infection infection group and allergic disease group,and the difference was statistically significant(F=9.50 P<0.01).Compared with the simple hypertrophy group,the allergic disease group was significantly reduced,and thedifference was statistically significant(P<0.01).Compared with the simple hypertrophy group,the recurrent respiratory infection group decreased,the difference was statistically significant(P<0.05);the recurrent respiratory infection group and the allergic disease group,the allergic disease group decreased,the difference was statistically significant.(P<0.05).conclusion:1.There were significant differences in the expression of TLR4,IL-6 and IL-35 in adenoid tissues of children with different diseases.2.The increase of TLR4 and IL-6 in adenoid tissues was the most obvious in children with adenoid hypertrophy complicated with allergic rhinitis and bronchial asthma,followed by those with recurrent respiratory tract infection.3.The expression of IL-35 in adenoid tissues was significantly decreased in children with hypertrophy of adenoids combined with allergic rhinitis and bronchial asthma,followed by repeated respiratory tract infections.4.TLR4,IL-6 and IL--35 levels are closely related to adenoid hypertrophy with allergic disease in children.