The Expression And Clinical Correlation Of The CD68 Factor In Acute Myeloid Leukemia

Objective: To analyze the expression and clinical characteristics of CD68 in bone marrow and peripheral blood of patients with acute myeloid leukemia(AML).Methods: The expression of CD68 in bone marrow blast cells was detected by four-color flow cytometry in 50 newly diagnosed AML patients and 23 normal controls.The expression of CD68 in peripheral blood of 85 newly diagnosed AML patients,29 remission AML patients and 24 normal controls was detected by ELISA.Result: 1.The median CD68 expression rate in myeloid leukemia cells of non-M3 acute myeloid leukemia patients was 19.7%,significantly higher than normal control 0.2%(P<0.001).2.The median concentration of non-M3 CD68 in peripheral blood was 67.97pg/ml,significantly higher than 29.94pg/ml(P<0.01)in normal control.3.There was no statistically significant difference in the plasma CD68 concentration of the peripheral blood between the newly diagnosed(45.72pg/ml)and the remission stage(55.12pg/ml)of non-M3 AML patients by paired analysis(P>0.05).4.The correlation between the expression rate of non-M3 AML bone marrow CD68,peripheral blood CD68 concentration and white blood cell count and other clinical data was compared respectively.The results showed that the higher the expression rate of CD68 in bone marrow,the higher the count of white blood cells in peripheral blood,and the lower the count of hemoglobin and platelet in peripheral blood.The higher the plasma concentration of CD68 in peripheral blood,the higher the white blood cell count and the lower the complete remission rate.Conclusion: The expression of CD68 both in bone marrow and peripheral blood of patients with non-M3 acute myeloid leukemia was higher than that of normal controls.Patients with high expression of CD68 had a low rate of complete remission,suggesting that the expression level of CD68 was correlated with treatment response.