Meta-analysis Of The Association Between Diabetes And Colorectal Cancer Incidence Rate

Objective:In recent years,studies conducted by different scholars on the correlation between diabetes and colorectal cancer have drawn significantly different or even opposite conclusions.In order to reach a conclusion with higher credibility and closer to the real situation,we conducted a comprehensive study on literatures related to the correlation between diabetes and colorectal cancer with the method of meta-analysis,and finally drew a conclusion on whether diabetes is related to the risk of colorectal cancer.Methods:We searched Pubmed,cochrane and Embase databases for relevant literature published as of August 23,2019,in addition to manual search.We have developed uniform inclusion criteria for search results.For the final included literatures,two analysts extracted and analyzed the data independently.We extracted the relevant basic information and research data of each study,and used Relative Risk(RR)as the effect volume for Meta analysis with Stata softwareResults:Diabetes has a significIn this study,a total of 14 references were included,with a total of 3773563 cases,including 509769 patients in the experimental group and 3083481 patients in the control group(no data of the experimental group and control group were available in the two literatures of larsson and Ma),and the total incidence of colorectal cancer(CRC)was 34575.Meta-analysis showed that the combined RR value was 1.26,95%confidence interval(95%CI)was[1.20,1.33],and the combined effect test value was Z=8.32,P=0.000.The subgroup analysis conducted according to the region showed that the combined RR of the European and American subgroups was 1.25,with 95%confidence interval(95%CI)[1.20,1.29],and the combined RR of the Asia Pacific subgroup was 1.27,with 95%confidence interval(95%CI)[1.09,1.48].Subgroup analysis based on gender showed that male subgroup RR=1.28,95%CI[1.18,1.38],female subgroup RR=1.23,95%CI[1.13,1.33].It can be seen that the risk of colorectal cancer in the diabetes group is 1.26 times higher than that in the control group.The risk of colorectal cancer in the diabetic group was higher than that in the non-diabetic group,no matt er in Europe,America or Asia Pacific region.Similarly,the risk of colorectal cancer was higher in men and women with diabetes than in those without diabetes.The P values of effect size in this meta-analysis and subgroup analysis were both less than 0.05,indicating that they were statistically significant.Conclusions:Compared with non diabetic patients,diabetics showed a higher incidence rate of CRC.Diabetes is a major risk factor for colorectal cancer.This conclusion is also true in different genders and regions.The causal relationship between diabetes and colorectal cancer is global and multi-ethnic.