| ObjectiveTo investigate the serum level of PG and G-17 combined with the level of carbohydrate antigen-19-9,carbohydrate antigen-125,carcino-embryonic antigen and carbohydrate antigens 72-4 and other tumor markers to screen value of gastric cancer,it provides the more solid theoretical support for the screening and diagnosis of clinical gastric cancer.Methods80 cases patients with early gastric cancer patients were collected from September 2016 to June 2018 in the first people’s hospital of Zhangjiagang including 46 male patients and 34 female patients,aged 38-64 years old with an average age of(54.13±12.84)years old;There were 60 patients with gastric benign ulcer,including 32 males and 28 females,aged 35-61 years,with an average age of(53.89±11.58)years;There were 50 patients with atrophic gastritis,including 23 male patients and 27 female patients aged 35-65 years with an average age(53.90±14.23)years;Patients with gastric benign ulcer and patients with atrophic gastritis were included in the benign lesion group;In addition,70 healthy adults were selected who underwent physical examination during the same period as the control group,including 41 male patients and 29 female patients,aged 30-64 years,with an average age of(53.69±10.42)years.Compared with the serum level of pepsinogen Ⅰ,pepsinogen Ⅱ and pepsinogen ratio of the three groups,to tested the level of gastrin-17,carbohydrate antigen 19-9,carbohydrate antigen-125,carcino-embryonic antigen and carbohydrate antigens 72-4 by enzyme linked immunosorbent assay,and investigated the relationship between the level of gastric function indexes and tumor markers and finded the diagnostic value.SPSS 20.0 statistical software was used for statistical processing of all data.Quantitative data with normal distribution of measurement data were expressed in the form of mean standard deviation(x±s),and t test was used for comparison between groups;Counting data was expressed as n(%)by chi-square,and the difference was not statistically significant by P<0.05.Results1.Compared with the gender,ages,height and body mass index of the three groups,the difference was not statistically significant(P>0.05);2.Compared with the control group,the serum level of PG I and PGR of the benign lesion group significantly decreased,but the level of G-17 significantly increased(P<0.05);Compared with the benign lesion group,the serum level of PG I and PGR of the gastric group significantly decreased,but the level of G-17 significantly increased,the difference was statistically significant(P<0.05);3.Compared with the control group,the serum level of CEA,CA199,CA125 and CA72-4 of the benign lesion group both significantly increased(P<0.05);Compared with the benign lesion group,the serum level of CEA,CA199,CA125 and CA72-4 of the gastric group significantly increased,the difference was statistically significant(P<0.05);4.Compared to before treatment,the serum level of the PG Ⅰ and PGⅠ/PG Ⅱ after treatment of different therapeutic effects both significantly increased,but the G-17 significantly decreased,the difference was statistically significant(P<0.05);5.Compared to before treatment,the serum level of the CA72-4,CEA,CA199 and CA125 after treatment of different therapeutic effects both significantly decreased,the difference was statistically significant(P<0.05);6.When gastric function index were detected alone,the highest specificity for early gastric is PG Ⅱ 73.78%,the highest sensitivity for early gastric is G-17 66.23%,the highest accuracy for early gastric is G-17 70.06%,the specificity,sensitivity and accuracy for early gastric of PG I+PGR+G-17 combined detection respectively 81.24%,77.57%and 82.51%;7.When tumor markers were detected alone,the highest specificity for gastric is CA72-4 72.54%,the highest sensitivity for early gastric is CA125 70.09%,the highest accuracy for early gastric is CA72-4 77.52%,the specificity,sensitivity and accuracy for gastric of CEA+CA199+CA125+CA72-4 combined detection respectively 82.54%,85.08%and 83.72%.8.When gastric function index combined with tumor markers,the specificity,sensitivity and accuracy of PGI+PGR+G-17 were all the highest,namely 90.69%,93.45%and 91.84%.ConclusionSerum PG I gastric function indices and PGR levels decrease,the rise of G-17,CA199 and CA125 tumor markers CEA,CA72-4 levels rise and development of the occurrence of gastric cancer have a certain correlation between the index level value can reflect the prognosis of patients with gastric cancer,gastric function indexes and joint detection of tumor markers index for early diagnosis of gastric cancer specificity of high sensitivity and accuracy,the prediction has a high screening value for the diagnosis of gastric cancer. |
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