| Objective:To measure the prevalence of diabetes among HIV-infected patients receiving highly active antiviral therapy(HAART)and to explore the influencing factors related to diabetes.So as to provide evidence for blood sugar management of HAART HIV-infected patients in the future.Methods:A cross-sectional study design is applied.400 HAART HIV-infected outpatients from a infections disease hospital in Yunnan Province are selected for structured questionnaire and physical examination.SPSS21.0 was used for statistical analysis,chi-square test was used for univariate analysis,univariable and multivariable logistic regression are performed to explore the determinants of diabetes.Results:1.The average age was 54.8±8.5 among 400 HAART HIV-infected outpatients.There are 252 males which account for 63.0%and 148 females accounting for 37.0%.There are 184 smokers which account for 46%and 159 drinkers accounting for 39.7%.21.4%of all are overweight and obese.37 cases of HAART HIV-infected outpatients have a family history of diabetes;it is reported that 117 had hypertensio,11 had hepatitis B,54 had hepatitis C,and 41 had hypercholesterolemia.2.Abnormal glucose tolerance was found in 112 cases,accounting for 28%of the total.The prevalence of diabetes was 9.0%among HIV-infected patients in this study.Twenty-seven(10.7%)of the 252 HIV-infected men has diabetes,and nine(6.1%)of the 148 HIV-infected women has diabetes.There were 76 glucose intolerance disorders cases in men which account for 30.1%,and 26 in women which account for 17.6%.The prevalence of diabetes in males was higher than that in females,and it has statistically significant difference(χ2=4.303,p=0.038).The prevalence of abnormal glucose tolerance in males was also higher than that in females(x2=9.678,P=0.002).There were 19 cases of diabetes at the age ranging from 40 to 59 years;17 cases of diabetes is 60 years old or above which account for 16.4%.The incidence of diabetes in people at the age of 60 or above was higher than that of at the age ranging from 40 to 59 years,and it was statistically different(χ2=11.433,P=0.001).3.Multivariable logistic regression analysis results showed that HIV-infected individuals aged 60 or above has 2.89 times risk of diabetes as 40-59 years old individuals(95%CI:1.440-5.810,p=0.003).The risk of diabetes for those with family diabetes history is 4.163 times as those without family history(95%CI:0.429-3.394,p<0.001).The prevalence of diabetes in patients with protease inhibitors was 2.521 times that of those without protease inhibitors(95%CI:1.091-5.830,p=0.030).Multivariable logistic regression analysis results show that male has 2.22 times risk of abnormal glucose tolerance as female individuals(95%CI:1.12-4.40,p=0.003).The risk of diabetes for those with family diabetes history is 4.16 times as those without family history(95%CI:0.42-3.39,p<0.001).The prevalence of diabetes in patients with protease inhibitors was 2.52 times that of those without protease inhibitors(95%CI:1.09-5.83,p=0.030).The risk of abnormal glucose tolerance for those with overweight and obesity is as 1.94 times respectively as those with normal body mass index individuals(95%CI:1.04-2.90,p=0.033)..Conclusion:1.It has a certain prevalence of diabetes among HIV-infected individuals.It is reminded that doctors should strengthen the patients’ blood sugger monitoring and management in their daily work.2.This study showed that old age,overweight and obesity,family history of diabetes are significant difference for diabetes among HIV-infected HAART outpatiends.3.It is related to diabetes whoes HAART with protease inhibitor,so patients with second-line treatment should pay more attention to blood glucose. |
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