Non-alcoholic Fatty Liver Disease And Its Risk Factors Among Enterprise Employees In Suzhou Industrial Park

ObjectiveNAFLD has become the most common chronic liver disease in the world,and the prevalence of fatty liver in China is also increasing,but the distribution of NAFLD among enterprise employees is not well understood.This study conducted a physical examination on 7,877 employees of the industrial park in the Suzhou Industrial Park Center for Disease Control and Prevention.The purpose of this study was to investigate the occurrence of NAFLD in the employees of the industrial park in Suzhou by understanding the prevalence of NAFLD and the risk factors related to fatty liver,Including its distribution and influencing factors.MethodsA total of 7,877 cases were collected in this survey,with the employees inspected by the units of the Suzhou Industrial Park Center for Disease Control and Prevention in 2017.The data of the subjects’ height and weight were collected,and their venous blood was collected for determination of alanine transferase(ALT),total cholesterol(TC),triglycerides(TG),fasting blood glucose(FPG),and uric acid(UA)content.According to the characteristics of each physical examination index and the presence or absence of NAFLD,the prevalence of NAFLD and related risk factors in this population were analyzed.The detection rate and composition ratio are used to describe the distribution of NAFLD at different levels among different ages,genders,BMI,ALT,TC,TG,FPG,and UA.Single-factor logistic regression models are used to analyze age,gender,BMI,and different levels.NAFLD relationship.In order to more accurately analyze the relationship between each indicator and NAFLD,a multi-factor logistic regression model was used to analyze the relationship between each indicator and NAFLD.Results1.This study involved 7,877 employees in Suzhou Industrial Park,including 5,305 males and 2,572 females,with a gender ratio of 2.06:1.A total of 1493 cases of NAFLD were confirmed,and the detection rates of men and women were 15.8%and 3.2%,respectively.There were 781 cases of mild NAFLD,the detection rate was 9.9%,and the detection rates for men and women were 12.0%and 5.5%,respectively.There were 712 cases of moderate-to-severe NAFLD,with a detection rate of 9.0%.The detection rates for men and women were 11.4%and 4.2%,respectively.As age increases,the detection rate of NAFLD also increases.There were differences in gender and age in NAFLD(P<0.05).Among the study subjects,the detection rate of mild NAFLD was 9.9%,and the detection rates of men and women were 12.0%and 5.5%,respectively.The detection rate of moderate to severe NAFLD was 9.0%,and the detection rates of men and women were 11.4%and 4.2%,respectively.There were differences in gender and age between different levels of NAFLD(P<0.05).2.Among the subjects,the distribution of BMI,blood pressure,ALT,TC,TG,FPG and UA was different among men and women(P<0.05).Mean age,mean BMI,systolic blood pressure,diastolic blood pressure,ALT,TC,TG,FPG,and UA were statistically different between different degrees of NAFLD(P<0.05).Body mass index was distributed among normal population and mild NAFLD.There were differences(P<0.05),and there were also differences in the distribution between normal population and moderate to severe NAFLD(P<0.05).After regression analysis,overweight and obesity were found to increase the risk of NAFLD.The distribution of systolic blood pressure,diastolic blood pressure,ALT,TC,TG,FPG and UA among normal population,mild NAFLD and moderate to severe NAFLD were all different(P<0.05).The distribution of systolic blood pressure,diastolic blood pressure,ALT,TC,TG,FPG and UA were different among normal population,mild NAFLD and moderate to severe NAFLD(P<0.05).3.Logistic regression analysis.After adjusting for multiple factors,compared with the normal BMI group,the risk of NAFLD in overweight was 5.31 times that of the normal group(OR=5.31,95%CI 4.42-6.38).The normal group was 19.83 times(OR=19.83,95%CI was 16.14-24.36),which was statistically different.The risk of NAFLD in the total cholesterol abnormal group was 2.83 times that of the normal group(OR=2.83,95%CI 2.18-3.67),which was statistically different.The risk of NAFLD in the fasting glucose abnormal group was 3.42 times that of the normal group(OR=3.42,95%CI 2.50-4.67),which was statistically different.Conclusion1.The detection rate of NAFLD in men in this group was higher than that in women.With age,the detection rate of both mild NAFLD and moderate NAFLD increased.2.Among the respondents,overweight and obesity are risk factors for NAFLD,and the risk of NAFLD is highest in the obese group.Obesity,blood sugar and blood lipid disorders are closely related to nonalcoholic fatty liver disease in employees of the park.