Biological Measurement And Analysis Of Intraocular Pressure And Related Tissue Structure In Myopia

Objective:Through the biological measurement and analysis of intraocular pressure and related tissue structure in myopia,Intraocular pressure,corneal thickness,corneal curvature,axial length and refractive error were correlated to analyze the changes of anterior segment structure related to the increase of intraocular pressure.to investigate the causes of a series of structural changes in the eyeball and their effects on intraocular pressure in patients with myopia.Methods:386 eyes of 193 ophthalmic outpatient patients were selected,including 132 males and 61 females.The age distribution of all participants was 17～50 years old,and the distribution of the equivalent spherical mirror degree was-0.50～-17.75D.All patients were excluded from other eye diseases(such as strabismus,nystagmus,blepharoptosis,corneal opacification,uveitis,cataract,macular degeneration,glaucoma,small palpebral fissure,etc.)and systemic diseases(such as diabetes,hypertension,etc.)that may affect eye measurement results.In addition,patients with a history of corneal contact lens wear,recent use of medications that may affect intraocular pressure and accommodation,eye surgery,or eye trauma were excluded All subjects were subjected to a computerized optometer to determine dioptre,and then to a standard cloud and mist master sense optometry on a comprehensive optometer.Record the degree of spherical equivalent(spherical degree+1/2 cylindrical degree);According to the results of subjective refraction,subjects were fully corrected,and+3D lens was added on the basis of complete correction to relax the ciliary muscle adjustment.After 5 minutes,non-contact tonometer was used to measure the intraocular pressure of the subjects,and IOLmaster was used to measure the eye axis and pentacam was used to measure the biological parameters of the anterior segment(such as the central and peripheral curvature of the anterior cornea surface,central and peripheral curvature of the posterior cornea surface,corneal thickness,anterior chamber depth,and anterior chamber Angle,etc.).The measured value of the non-contact tonometer was input into pentacam,and the relative corrected iop value was obtained based on the measured data of the anterior segment of pentacam using its built-in Orssengo/Pye correction formula.According to the spherical equivalent less than-3.00D,-3.00～-6.00D and greater than-6.00D,the three groups were divided into low,medium and high groups and analyzed.Among the 386 eyes of 193 patients,288 eyes of 144 patients(total corneal refractive power less than 44D and axial length greater than 23.5mm)were selected for analysis separately,and were divided into low,medium and high groups according to the spherical equivalent less than-3.00D,-3.00～-6.00D and greater than-6.00D.And were divided into two groups according to the axial length of 26.5mm as the boundary for analysis.Results:①Overall,The correlation between the axial length and the spherical equivalent is good(r=0.772,P<0.01).After the whole group was divided into high,medium and low degree myopia groups,the axial length was positively correlated with the curvature radius of each part of cornea in each group.There was no correlation between the axial length and the spherical equivalent in patients with low myopia(P>0.05).The correlation between the axial length and the spherical equivalent was higher in the high myopia group(r=0.858;P<0.01),and the correlation coefficient between the axial length and the curvature radius of each part of the cornea in the high myopia group was further increased than that in the moderate myopia group.In addition,there was a positive correlation between the spherical equivalent and the radius of curvature of each part of the cornea in patients with high myopia,and with the increase of myopia degree and the elongation of eye axis,corneal thickness gradually becomes thinner.②From the exclusion of corneal refractive power greater than 44D and axial length less than 23.5mm after the crowd.Intraocular pressure has nothing to do with the width of anterior chamber Angle.according to the low,medium and high myopia group,the correlation between low axial myopia anterior chamber volume(r=0.342;P=0.001<0.01),moderate axial myopia anterior chamber volume(r=0.234;P=0.005<0.01),low axial myopia anterior chamber depth(r=0.235;P=0.026<0.05),moderate axial myopia anterior chamber depth(r=0.227;P=0.007<0.01)and intraocular pressure according gradually weakened in the order of low,medium and high myopia.Up to high myopia,Intraocular pressure is completely unrelated to anterior chamber volume(r=0.132;P=0.345>0.05)and anterior chamber depth(r=0.180;P=0.198>0.05).Axial myopia was divided into two groups according to the axial length of 26.5mm:the intraocular pressure(P<0.05)and the radius of curvature of the anterior and posterior surfaces of the central and peripheral cornea(P<0.01)were significantly higher in the>26.5mm axial length group than in the<26.5mm axial length group.The corneal volume(P<0.05)in>26.5mm axial length group was significantly smaller than that in<26.5mm axial length group.Conclusion:not only the sclera was remodeled and was elongated,but also the cornea underwent a series of changes:for example,the cornea became more and more flat with the increase of the axial length,and the cornea became weaker with the increase of the axial length and the spherical equivalent.Cornea is the main factor affecting the bias of intraocular pressure measurement,so the measurement of intraocular pressure in myopia(especially high myopia)must be accurately evaluated by multi-factor analysis.Figure 11 table 11 reference 65...