Relationship Between Serum Apelin And AngⅡ And Carotid Intima-media Thickness In Patients With Type 2 Diabetes Mellitus

ObjectiveTo explore the relationship between serum Apelin and AngⅡand the thickness of carotid intima-media thickness in type 2 diabetes（T₂DM）.Methods:103 patients with T₂DM were selected in total in this study.All the patients were divided into two groups based on the thickness of CIMT:normal CIMT（CIMT<0.9mm,NCIMT,n=48）and abnormal CIMT（CIMT>0.9mm,ACIMT,n=55）,Healthy Individuals were selected as the normal control group（NC,n=49）.Clinical and biochemical parameters were detected among three groups.Body mass index（BMI）,waist-hip ratio（WHR）,systolic blood pressure（SBP）,diastolic blood pressure（DBP）,fasting glucose（FPG）,HbA1c,total cholesterol（TC）and triglyceride（TG）were measured for all the selected individuals.Besides enzyme-like immunosorbent assay was used to determine fasting serum Apelin and AngⅡlevels of all the people.and SPSS 24.0 was used for statistical analysis.Results:Compared with the NC group,Serum Apelin levels in the NCIMT group were increased[（2031.88±389.04）vs（2483.43±345.22）pg/ml,P<0.01].The level of Apelin in the NCIMT group was higher than that in the ACIMT group,（2483.43±345.22）vs（2243.98±419.35）pg/ml,P<0.01;Compared with NC group,serum AngⅡlevel was increased in NCIMT group and ACIMT group[（94.56±35.28）vs（112.23±38.31）vs（125.82±35.03）pg/ml,P<0.01].Correlation analysis showed that the serum Apelin was positively correlated with WC,TC,FPG,HbA1c（r=0.223,0.271,0.227,0.580,P<0.05 or P<0.01）;Serum AngⅡwas positively correlated with HbA1c and TC（r=0.459,0.267,P<0.05 or P<0.01）.Logistic binary regression analysis showed that age、SBP、HbA1c and AngⅡwere positively correlated with CIMT thickening,while Apelin was negatively correlated to CIMT（P<0.05）.Conclusion:Serum Apelin may be a protective factor for CIMT,while AngⅡlevel may be a risk factor for CIMT,which may be correlated with the development of atherosclerosis in T₂DM.