Retrospective Study Of Risk Factors For Hemorrhagic Transformation After SA Disease

Objective:Through the retrospective analysis method summary,SA disease of Hemorrhagic transformation(Hemorrhagic transformation,HT)risk factors.To understand the risk factors of hemorrhagic transformation in patients with SA disease(Ischemic hemorrhagic transformation)and to improve the prognosis of patients with SA disease with early intervention.Methods:In January 2017-April 2019 in Inner Mongolia national university affiliated hospital and Inner Mongolia forestry general hospital hospital treatment on the basis of cerebrovascular disease classification,2015 of the People’s Republic of China,the head CT and/or MRI diagnosis of ischemic Mr Disease and the acute ischemic Mr Gives birth to patients,68 cases of hemorrhagic transformation of backwardness as hemorrhagic transformation(HT)group.A total of 116 concurrent hospitalized patients with ischemic sarcoma without hemorrhagic transformation were selected as the control group.The basic data and relevant clinical data of the included cases were analyzed and summarized,including:general information:age and gender;Personal history:Alcohol and tobacco use;Previous history:history of stroke,diabetes,hypertension,hyperlipidemia,atrial fibrillation;Clinical data:onset time,NIHSS score and mRS score on admission;Laboratory tests:white blood cells,platelets,neutrophil percentage,triglycerides,total cholesterol,HIGH-density lipoprotein cholesterol,and low-density lipoprotein cholesterol.Imaging data:infarct area or volume,white matter loose(grade),etc.Treatment:thrombolytic therapy and routine therapy.To explore the risk factors of hemorrhage after SA disease.Logistic regression analysis was used to study the risk factors affecting HT.Results:(1)Two groups of patients with general information,according to the results of the HT group and non HT group in gender,age,history of stroke,hypertension,diabetes,hyperlipidemia,anticoagulant therapy,such as smoking and drinking data no significant statistical difference(P st13 0.05),but the history of atrial fibrillation,NIHSS score and MRS score statistical differences between the two groups of patients(P<0.05).(2)t-test analysis of blood routine data of patients in the two groups showed that there was no statistically significant difference in the percentages of white blood cells,platelets and neutrophils between the two groups(all P>,0.05).The results of serum lipid index analysis in the two groups showed that the total cholesterol,triglycerides,serum LDL cholesterol and serum HDL cholesterol levels in the HT group were all higher than those in the non-ht group(P>0.05)..(3)Ten patients(14.71%)had hemorrhagic transformation within 24 hours(≤24)after S A disease.There were 44 cases of hemorrhagic transformation from 24 hours to 7 days(24<time<7),accounting for 64.7%,and 14 cases of hemorrhagic transformation from 7 days(≥7),accounting for 20.59%.In the hemorrhagic transformation group,21 cases(30.88%)had aggravated clinical symptoms.After treatment,4 cases(19.05%)had aggravated symptoms,12 cases(57.14%)had improved clinical symptoms,and 5 cases(23.81%)had no change in symptoms.Thrombolytic therapy was performed in 15 patients in the bleeding transformation group,with a thrombolytic rate of 22.06%,while in 9 patients in the control group,with a thrombolytic rate of 7.76%,P<0.05,showing a statistically significant difference.(4)Taking whether hemorrhagic transformation occurred after SA disease as the dependent variable,multivariate Logistic regression analysis showed that the history of atrial fibrillation,NIHSS score at admission,MRS score,hypertension,infarct area,white matter lesions and other factors were all influential factors for the hemorrhagic transformation of SA disease patients.However,gender,age,smoking,drinking,diabetes and other factors were not the risk factors for hemorrhagic transformation in patients with SA disease.Conclusion:The history of atrial fibrillation,NIHSS score at admission,MRS score,hypertension,infarct size,and leugoencephalopathy were all important risk factors for hemorrhagic transformation in patients with SA disease,and the risk of hemorrhagic transformation in patients with SA disease was significantly increased in patients with combined af history,NIHSS score,and higher MRS score.