| Objective By observing the effects of beinaglutide and liraglutide on the body weight,waist circumference and visceral adipose tissue content of adult patients with type 2 diabetes,the efficacy of beinaglutide And liraglutide in improving visceral fat accumulation was compared.Methods According to the inclusion and exclusion criteria,this study selected from November 2018 to May 2020 in dalian municipal central hospital endocrinology clinic of metformin single-agent or metformin(greater than or equal to 1500 mg per day)combined therapy with sulfonylureas blood sugar not done in adult patients with type 2 diabetes of 37 patients as the research object(conform to the WHO in 1999 Diabetes Diagnosis and Classification Standard),7.0-12% Hb A1 c,unchanged hypoglycemic therapy for nearly three months.During the two weeks of induction period,sulfonylureas were discontinued and metformin was maintained at the original dose.They were randomly divided into beinaglutide group and liraglutide group.At baseline,the patient’s past history,medication history,age and other general information were collected.Clinical biochemical indexes were monitored at baseline and 14 weeks after treatment,including blood glucose,blood lipid,liver function,kidney function and other routine biochemistry.Body weight,BMI,body fat mass,body fat percentage,waist-to-hip ratio,visceral fat area and skeletal muscle mass were measured with the body composition analyzer Inbody720 produced in Korea.Philips IE Elite type of color doppler ultrasonic diagnostic instrument measured Epicardial fat thickness(Epicardial Adipose Tissue,EAT).Prodigy Primo dual-energy X-ray absorptiometry measured body weight,BMI,body fat mass,abdominal Android fat(Android fat),abdominal Android fat percentage(Android %fat),hip Gynoid fat(Gynoid fat),hip Gynoid fat percentage(Gynoid %fat).SPSS21.0 statistical software was used for data analysis,and thestatistical difference was P<0.05.Results1.Baseline status:In this study,37 people were enrolled,among whom 2 in the beinaglutide group and 1 in the liraglutide group were withdrawn from the group due to nausea and vomiting intolerance.A total of 34 people completed the experiment.There were no statistically significant differences in general information and routine biochemical indicators,waist circumference,body weight,BMI,body fat mass,body fat percentage,waist-to-hip ratio,visceral fat area,skeletal muscle mass,EAT,Android fat,Android% fat,Gynoid fat,Gynoid% fat between the beinaglutide group and the liraglutide group(P>0.05).2.Changes in body weight and waist circumference during treatment: the body weight and waist circumference of both beinaglutide group and liraglutide group decreased with the extension of treatment time.3.Terminal condition:3.1 After treatment,FPG,2h PG,Hb A1 c,waist circumference,body weight,BMI,body fat mass,body fat percentage,waist-to-hip ratio,visceral fat area,Android fat,Android% fat,Gynoid fat and Gynoid% fat in beinaglutide group decreased significantly from baseline(P<0.05).However,there was no significant difference in TC,TG,HDL-C,LDH-C,EAT and skeletal muscle mass before and after treatment(P>0.05).3.2 After treatment,FPG,2h PG,Hb A1 c,waist circumference,body weight,BMI,body fat mass,body fat percentage,waist-to-hip ratio,visceral fat area,Android fat,Android% fat,Gynoid fat and Gynoid% fat in liraglutide group decreased significantly from baseline(P<0.05).However,there was no significant difference in TC,TG,HDL-C,LDH-C,EAT and skeletal muscle mass before and after treatment(P>0.05).3.3 After treatment,the decrease of waist circumference,body weight,BMI,body fat mass,body fat percentage,waist-to-hip ratio,visceral fat area,Android fat and Gynoid fat in the beinaglutide group was better than that in the liraglutide group(P<0.05).4.Pearson correlation analysis showed that visceral fat area was correlated with body weight,waist circumference,BMI,body fat mass,body fat percentage,waist-to-hip ratio,Android fat,Android% fat,Gynoid fat and Gynoid% fat(r=0.711,P=0.000;r=0.499,P=0.003;r=0.754,P=0.000;r=0.930,P=0.000;r=0.772,P=0.000;r=0.617,P=0.000;r=0.854,P=0.000;r=0.742,P=0.000,r=0.746,P=0.000;r=0.556,P=0.001).5.Multiple linear regression analysis,the regression equation was obtained:visceral fat area =-28.778+2.900 body fat mass +63.110 waist-to-hip ratio.Body fat mass and waist-to-hip ratio were positively correlated with visceral fat area(β=2.900,P<0.05;β=63.110,P<0.05).Conclusion1.Beinaglutide has similar hypoglycemic effect with liraglutide.2.Beinaglutide can reduce blood sugar and also reduce body weight,waist circumference and visceral fat accumulation.3.Beinaglutide is better than liraglutide at reducing weight,waist circumference and visceral fat accumulation. |
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