| BackgroundSchizophrenia is a common severe mental illness in the psychiatric department.It mainly shows positive symptoms,negative symptoms and cognitive disorders.It is generally believed that if the first-time patients can be treated promptly,the prognosis of regular medication is better.Because of the specificity of physiological functions of female patients,they are more sensitive to the effects and side effects of drugs.Repetitive transcranial magnetic stimulation as a non-invasive physical therapy method,combined with the therapeutic and side effects of aripiprazole,the combination of the two may have a better effect on patients’ mental symptoms and cognitive function,and it is an advantage for women patients.This study will focus on the impact of rTMS combined with aripiprazole on the clinical efficacy and cognitive function of first-episode female schizophrenia.ObjectivesObserving the effect of rTMS combined with aripiprazole on the clinical efficacy and cognitive function of first-episode female schizophrenia,and to analyze its safety,so as to provide a theoretical basis for clinical treatment of first-episode female schizophrenia.Methods1 From December 2018 to September 2019,80 first-time female schizophrenics from Luoyang Fifth People’s hospital were randomly divided into two groups: the experimental group(rTMS combined with aripiprazole group)and the control group(aripiprazole group).In the test group,the positive symptoms were given 1 Hz low-frequency rTMS combined with aripiprazole,and the negative symptoms were given 10 Hz high-frequency rTMS combined with aripiprazole,and the control group was given only aripiprazole,among which 37 cases in the experimental group and 36 cases in the control group completed the experiment..Before treatment and after 6 weeks of treatment,PANSS scales were used for psychotic assessment,and the neurocognitive function of patients was assessed using the event-related potential P300 latency and amplitude and the MATRICS Consensus Cognitive Battery.The use of the secondary response scale was used to assess its security.2 Thirty healthy people were selected as the normal group,and the cognitive function was measured by P300 latency and amplitude and MCCB scale before treatment.3.Spss25.0 software was used for statistical analysis.The results of measurement data(age,course of disease,education years)were expressed by means of mean ± standard deviation(sx ±).For all the results,the normality test was carried out first.The results of before and after treatment were compared by paired sample t-test,the results were compared between two groups using independent sample t-test,and the results between multiple groups were compared using single factor analysis of variance.P<0.05 was statistically significant.Results1.The result of PANSS scales evaluation.There was no significant difference in the scores of the PANSS scales between the two groups before treatment(all P<0.05).Compared with before treatment,the positive symptoms,negative symptoms,general pathological symptoms,and total PANSS scores of the two groups of patients all decreased,and the difference was statistically significant(all P<0.05).The positive and negative symptoms and the total score of PANSS decreased in the test group and the control group,and the differences were statistically significant(all P<0.05).2.The result of Event-related potential P300.1)P300 latency: At the baseline level,the latency of the experimental group and the control group was longer than that of the normal group,the difference was statistically significant(all P>0.05).There was no significant difference in latency period between the experimental group and the control group before treatment(all P>0.05).After 6 weeks of treatment,the incubation period of the experimental group and the control group was shorter than that before treatment,the difference was statistically significant(all P<0.05)..There was significant difference in incubation period between the experimental group and the control group before and after treatment(all P<0.05).Compared with the normal group,there was a statistically significant difference in latency between the two groups before and after treatment(all P< 0.05).2)P300 amplitude: At the baseline level,the amplitude of the experimental group and the control group decreased compared with the normal value,and the difference was statistically significant(P<0.05).The difference in amplitude between the test group and the control group before treatment was not statistically significant(P<0.05).After 6 weeks of treatment,the amplitude of the test group and the control group were prolonged,and the difference was statistically significant(P<0.05).Before treatment and after 6 weeks of treatment,there was a statistically significant difference in the amplitude reduction between the test group and the control group(all P<0.05).Both before and after treatment,the amplitude of the two groups of patients decreased compared with the normal group,and the difference was statistically significant(all P<0.05).3.The result of MCCB scales evaluation.At the baseline level,compared with the normal group,the difference in the MCCB scale scores of the experimental group and the control group was statistically significant(all P<0.05).There was significant difference in information processing speed,attention/alertness,working memory,word learning,visual learning,reasoning and problem solving and social cognition before and after 6 weeks of treatment in the experimental group(all P<0.05).There were significant differences in information processing speed,attention/alertness,word learning,visual learning,reasoning,problem solving and social cognition before and after treatment in the control group(all P<0.05).There was significant difference in working memory between the experimental group and the control group after 6 weeks of treatment(P<0.05).There was a statistically significant difference in attention/alertness difference(P=0.01),working memory difference(P<0.05)and word learning difference(P=0.04)between the experimental group and the control group after 6 weeks of treatment.There were significant differences in the experimental group and the control group compared with the normal group(all P<0.05).4.There was no significant difference between the experimental group and the control group in the incidence of adverse reactions and the scores of the TESS scale(all P>0.05).Conclusions1.Compared with the control group,rTMS combined with aripiprazole can significantly improve the mental symptoms of the first female schizophrenia patients.2.rTMS combined with aripiprazole treatment can improve cognitive functions such as information processing speed,attention / alertness,working memory,word learning,visual learning,reasoning and problem solving,and social cognition.Compared with the control group,it is more prominent in improving attention/alertness,working memory and word learning.3.Compared with the control group,there were no special adverse reactions in the rTMS combined with aripiprazole group. |
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