Clinical Value Of PCT Combined With Amylase Detection Of Abdominal Drainage Fluid In The Early Diagnosis Of Anastomotic Leakage After Radical Gastrectomy Of Gastric Cancer

Objective:To explore the Clinical value of PCT combined with amylase detection of Abdominal drainage fluid in the early diagnosis of anastimotic leakage after radical gas--trectomy of gastric cancer.Methods:This study selected from October 2018 to December2019 in our hospital from gastrointestinal subject lines of the 150 patients of gastric cancer radical as the research object,the close monitoring of postoperative abdominal drainage fluid amylase(postoperative 1,2,3,4,5 days)and serum PCT(1,3,5 days),according to the presence of anastomotic leakage occurs,it is divided into AL group and non-AL group,the contrast analysis of two groups of postoperative serum PCT(Procalcitonin)and abdominal cavity drainage fluid amylase levels,and draw the receiver-operating characteristic curve(ROC curve)to evaluate the PCT and abdominal cavity drainage fluid amylase diagnostic value in gastric cancer postoperative anastomotic leakage.Results:A total of 150 patients were included,112 males and 38 females,11 of whom had anastomotic leakage and 139 were normal.Compared with the general data,the operative time(P=0.03)and intraoperative blood loss(P=0.013)were all P<0.05,with statistically significant differences.There were statistically significant differences in thelevels of day 2,3,4,and 5(P> 0.05)and the level of PCT at day 1,3,and 5(P<0.05).The AUC value of amylase reached its maximum value(0.859)on the 5th day after the operation,with cut-off value of 400U/L,sensitivity of 81.8%,specificity of100%,ppv100% and npv97%.On the third day after the operation,the AUC value of PCT was the largest(0.956),with the cut-off value of 1.62ng/ml,sensitivity 90.9%,specificity 93.5%,ppv55% and npv99%.Conclusion: Postoperative dynamicmonitoring of PCT and AMY has a certain predictive value for early detection of Anastomotic Leakage after Radical Gastrectomy.