Clinical Observation On Treatment Of Gastroesophageal Reflux Disease With Deficiency With Middle Deficiency And Inverse Qi Based On The Theory Of "One Qi Circulation"

Bbjective:Based on the theory of One Qi Circulation,the prescription uses Xiangsha Liujunzi Decoction as the basic prescription to treat gastroesophageal reflux disease with syndrome of deficiency and adverse qi.By comparing with western medicine pantoprazole enteric-coated tablets,the total effective rate of clinical treatment,the improvement of symptoms,GERD-HRQL scale score,recurrence rate and the total effective rate of clinical treatment for RE patients are observed,so as to evaluate the clinical efficacy of gastroesophageal reflux disease patients treated with traditional Chinese medicine.Methods: The patients in this study were from June 1,2018 to December 31,2019 in the outpatient clinic of Dr.Yang Jiayao of Wuhan Integrated Chinese and Western Medicine Hospital.84 patients who were diagnosed with GERD after examination and examination and met the inclusion criteria were randomized,42 cases were randomly divided into treatment group and control group.The data of gender,age,course of disease, symptoms,history of tobacco and alcohol,GERD-HRQL scores,gastroscopy scores of the two groups of patients were statistically processed without significant differences(P>0.05)and were comparable.Treatment group: The principle of treating Jianpi Yiqi Huashi Liqi is based on Xiangsha Liujunzi Decoction.Take 1 dose daily,divided into two servings,half an hour before meals.Control group:pantoprazole sodium enteric-coated tablets 40 mg po bid,taken on an empty stomach for half an hour.Eight weeks is a course of treatment.Observe the TCM symptom scores,gastroscopy results,GERD-HRQL scores,and RDQ scale scores before and after treatment in both groups.The data collected in clinic were analyzed using SPSS25.0 statistical software.Results:(1)Comparison of the total effective rate of treatment of GERD patients in the two groups:20 cases were cured in the treatment group,8 cases were markedly effective,9 cases were effective,and 5 cases were ineffective;18 cases were cured in the control group,6 cases were markedly effective,6 cases were effective,and 12 cases were ineffective;treatment The total effective points of the treatment group and control group became 88.1% and 71.4%,and there was no significant difference between the two groups(P> 0.05).This indicates that the treatment group has the same effect on GERD as the control group.(2)Comparison of improvement of each symptom in the two groups:The treatment group can effectively improve the above symptoms for common symptoms such as heartburn,pantothenic acid,post-sternal burning pain,nausea,pharyngeal discomfort,dysphagia,abdominal pain,belching,and epigastric distension.The control group could effectively improve the above symptoms except dysphagia(P <0.05).Except that the control group could not improve the symptoms of dysphagia,both the treatment group and the control group could improve the symptoms.(3)Comparison of the difference in the scores of the symptoms between the two groups:The spleen-enriching and qi-enriching wet treatment group was better than the control group in improving heartburn,nausea,and abdominal distension(P<0.05),and it improved the other symptoms in the two groups There was no statistical difference(P> 0.05).This shows that the treatment group can effectively improve symptoms when treating GERD.(4)Comparison of the GERD-HRQL scale score and satisfaction before and after treatment in the two groups:The GERD-HRQL scale score of the treatment group and the control group decreased significantly(P <0.05).The difference in the decrease in the GERD-HRQL scale score between the two groups was compared,and the score in the treatment group was significantly reduced(P <0.05).Satisfaction with the health-related quality of life of GERD:32 were satisfied in the treatment group,10 were average,and 0 were dissatisfied;18were satisfied in the control group,12 were average,and 12 were dissatisfied.The satisfaction rate of GERD-HRQL in the treatment group was 76.2%,which was significantly better than42.9% in the control group(P <0.05).(5)Comparison of recurrence rates between the two groups:20cases were cured in the treatment group and 3 cases were relapsed;18 cases were recovered in the control group and 8 cases were relapsed.The recurrence rate in the treatment group was 15.0% lower than 44.4%,and the difference between the two groups was statistically significant(P <0.05).This shows that the treatment group can effectively reduce the recurrence rate.(6)Comparison of the total effective rate of treatment of RE patients in the two groups:There were 36 RE patients in the treatment group,of which 12 were cured,10 were effective,9 were effective,and 5 were ineffective;in the control group,There were 32 RE patients,of which 9 were cured,7 were markedly effective,5 were effective,and 11 were ineffective;the total effective rate in the treatment group was 86.1%,which was better than 65.6% in the control group,and 2 The difference between the groups was statistically significant(P <0.05),indicating that the treatment group was better than the control group in terms of improvement of gastric mucosa.Conclusion: Both the treatment group and the control group were able to treat GERD with Deficiency of Qi deficiency syndrome,and compared with the control group,the treatment group achieved better symptom improvement,health-related quality of life,relapse rate and gastric mucosa improvement.It is suggested that based on the guidance of the theory of one-qi circulation,the rule of strengthening the spleen and replenishing qi and relieving dampness is the rule,and Xiangsha Liujunzi Decoction is used as the basic prescription and worth further research and promotion.