Therapeurtic Effects And Safetf Of Shi Hu Yu Nv Decoction Unite Iguratimod Treating Types Of Stomach-heat And Asthenia Of Renal Yin Sjgren’s Syndrome

Objective:To observe the clinical efficacy and safety of Shi Hu Yu Nv decoction unite Iguratimod treating types of stomach-heat and asthenia of renal yin Sjgren’s syndrome.Methods:We slected 74 stomach-heat and asthenia of renal yin Sjgren’s syndrome patients as research object,those outpatients and inpatients seen medical advice in our department during January 2018-July 2019,They were divided into observation group and control group according to the digital table method,each group of 37 exemples.Control group were treated by Iguratimod orally(Iguratimod 25 mg bid po);Observation group treated by Shi Hu Yu Nv decoction unite Iguratimod orally,(Iguratimod 25 mg bid po,at the same time take decoction of Shihu 10 g Shigao 10 g Shengdi 15 g Maidong 9g Zhimu 9g Chuanniuxi 9g 500 ml cold water,soak for an hour,then start to fry,fry to100-150 ml liquid,fry twice,after two times of mixing,100-150 ml of the solution was taken each time.(Taken cool).The two group treatment courses were 12 weeks.Observe two groups of patient,s clinical symotoms,signs,laboratory exeamination results.(Immunoglobulin,serum protein,ESR,RF,RT,Liver and Kidney function,Blood sugar,Blood fat)、ESSPRI scores、ESSDAI scores、Schirmer trial and SFR scores.Laboratory examination results and scores were recorded at the first visit,at the second visit after 1 month and at the third visit after 12 weeks.SPSS21.0 statistical software was used to analyze all the data,and T-test、rank sum test and other test methods were used to,P<0.05 had statistical significance.Results:After 12 weeks treatment the total effective rate in the observation group was 94.59%,which was superior to 78.38% in the control groups(P<0.05).After 1month treatment,control group compared to the time of admission,ESR、RF、IgG have decline;PLT count have increased,but the decline of ESR 、RF、IgG were not statistically significant(P > 0.05).the increased of the PLT was statistically significant(P <0.05).Observation group ESR、RF、IgG were decline after 1 month treatment,PLT count have increased,compared to the time of admission,the decline of ESR、RF were not statistically significant(P > 0.05).the increased of the PLT and IgG was statistically significant(P<0.05).After 12 weeks treatment two groups of the serum IgG content(23.19±5.06vs16.86±5.65),ESR(28.95±6.98vs24.38±6.15),RF(35.30±9.56vs24.78±7.40),PLT(81.86±8.23vs98.30±15.22).the ESR、RF and IgG of observation group were lower than the co ntrol group,the difference was statistically significant(P<0.05).PLT count was highe r than the control group,the difference was statistically significant(P<0.05).After 1month treatment,the ESSDAI 、 ESSPRI scores of two group were decline.Schirmeri、SFR scores were increased.The control group compared to the time of admission,the decline of ESSDAI scores、ESSPRI scores、Schirmeri scores、SFR scores,the difference was not statistically significant(P >0.05).Observation group ESSDAI scores、Schirmeri scores compared to the time of admission the difference was not statistically significant(P>0.05).ESSPRI scores、SFR scores compared to the time of admission the difference was statistically significant(P<0.05);compare the two groups,ESSDAI scores、ESSPRI scores、Schirmeri scores the difference was not statistically significant(P>0.05);SFR scores the difference was statistically significant(P<0.05).After 12 weeks treatment two groups of the ESSDAI(9.92±2.35vs7.76±2.15;10.08±2.08vs5.76±1.34)、 ESSPRI(7.81±1.22vs5.78±1.03;8.84±1.33vs4.32±0.91)was declined.After treatment Schirmeri scores(1.25±0.42vs4.22±0.70;1.40±0.32vs5.74±0.78)、 SFR scores(0.50±0.10vs0.91±0.21;0.56±0.10vs1.13±0.41)was increased,After treatment observation group ESSDAI scores、ESSPRI scores were lower than that in contral group.Schirmeri scores、SFR scores higher than contral group,the difference was statistically significant(P<0.05).Both of two groups the adverse reaction rate were all 18.91%,There was no significant difference in the adverse reaction rate between the two groups(P>0.05).Conclusion : 1.Shi Hu Yu Nv decoction unite Iguratimod treating types of stomach-heat and asthenia of renal yin Sjgren’s syndrome,the clinical and laboratory indicators can be significantly improved.2.Shi Hu Yu Nv decoction unite Iguratimod treating types of stomach-heat and asthenia of renal yin Sjgren’s syndrome the curative effect is definite.And with simple applicate Iguratimod treatment compared,the adverse reaction rate was not difference.