GD-EOB-DTPA Enhanced MR Imaging And T1mapping Assessment Liver Function In Patient With Hepatic Alveolaralveolar Echinococcosis

Objectives:To investigate the value of Gd-EOB-DTPA enhanced scan and T1-mapping imaging in evaluating the residual liver function of patients with hepatic echinococcosis.Method:Collected the first affiliated hospital of Xinjiang Medical University from January 2017 to January 2018 to treat patients with hepatic echinococcosis,and preformed magnetic examination,including conventional plain scan and enhanced sequence,and T1-mapping sequence,According to the liver function Child-Pugh score,patients were divided into three groups: A(n=11),B(n=9),and C(n=5).The image were transmitted to the Siemens post-processing workstation for data measurement.Child-PughA,B,Cgroups of patients with liver parenchyma and hepatobiliary signal strength before T1 value,hepatobiliary phase T1 value,calculate the relative enhancement(RE)and T1 relaxation time reduction rate(△T1).Univariate analysis of variance was used to compare the values of different liver functions,Spearman correlation analysis was used to evaluate the correlation between measured values and liver function,and ROC curves were used to analyze the diagnostic efficacy of RE and T1 relaxation time reduction rates for various liver functions.Result:1.With the decline of liver function,hepatic parenchymal signal intensity decreases during the hepatobiliary phase,the relative enhancement of the liver(RE)value,the decrease of T1 relaxation time decreases,and the T1 value of plain scan and the T1 value of hepatobiliary phase increase as the liver function decreases.There were significant differences in SI hepatobiliary period,RE,plain T1 value,hepatobiliary phase T1 value,and T1 relaxation time reduction rate among the groups(P <0.05).There was no significant difference in SI plain scan between the groups.Significance(P> 0.05).2.There was no significant correlation between the signal intensityof plain scan and the grade of liver function(r=-0.306,P=0.035),and there was a significant negative correlation between the signal intensity of hepatobiliary phase and grade of liver function(r=-0.824,P<0.001);RE value was significantly negatively correlated with liver function grade(r=-0.786,P<0.001);plain scan T1 was significantly positively correlated with liver function grade(r=0.823,P<0.001).Liver function grades were significantly positively correlated(r=0.823,P<0.001);△T1% was significantly negatively correlated with liver function grades(r=-0.859,P<0.001).3.Relative enhancement degree(RE),T1 relaxation time reduction rate(△T1),the area under the ROC curve(AUC)of liver function in Child-PughA group and Child-PughB group were:(0.869,0.791)The area under the ROC curve of the PughB group and the Child-PughC group were(0.956,0.826),and the area under the ROC curve of the Child-PughA group and the Child-PughB and Child-PughC groups were(0.916,0.987).For Child-PughA.B patients,the diagnostic value of RE value is better than △T1,and for Child-Pugh patients,the diagnostic value of △T1 value is better than RE value.Conclusion:Gd-EOB-DTPA enhanced magnetic resonance signal intensity and T1 mapping imaging help clinical evaluation of liver function.