Improving The Prediction Of Open Cardiac Surgery-Associated Acute Kidney Injury(AKI)

Introduction: Postoperative acute kidney injury is linked to higher mortality,and more complicated hospital course with longer hospital stay.Urinary kidney injury molecule 1(KIM-1)may play a key role as an early predictor of acute kidney injury post-cardiopulmonary in open heart surgery.Methods: We evaluated 45 patients who underwent open-heart surgery from January 2017 to October 2017.Both urinary kidney injury molecule 1 and serum creatinine were assessed before operation,3hs,and 24 hs after operation.Acute kidney injury was diagnosed according to KDIGO 2012 guidelines.Results: In our study,27 patients developed acute kidney injury.The 3hour-post-surgery urinary kidney injury molecule 1 was significantly higher in the acute kidney injury group(P<0.015)but,we did not find any significant difference in the serum creatinine levels between the two groups.Conclusion: despite that serum creatinine is still gold standard for AKI diagnosis,early diagnosis of AKI is still challenging,therefore searching for other new markers is necessary,Urinary KIM-1 can be used as a simple noninvasive and specific biomarker for early diagnosis of AKI...