Objective:To explore the effect of elemene injection combined with TACE on the quality of life,TCM symptoms,liver and kidney function,immune function,adverse reactions and tumor remission rate of patients with primary liver cancer.Methods :From December 1,2018 to December 31,2019,80 patients with primary middle and advanced stage liver cancer aged 18 to 75 years were selected from the central theater General Hospital of the Chinese people’s Liberation Army.They were divided into experimental group and control group according to the principle of randomization.The biochemical indexes and chest CT were examined before operation.After local anesthesia at the puncture site of right groin with improved Seldinger technique,the right femoral artery was punctured,the microcatheter was super selected into the target blood vessel,and the intravascular chemoembolization was performed.The test drug and administration: the control group:Cisplatin 30 mg ~ 50 mg + 5-FU 800 ~ 1000 mg,followed by iodized oil6 ml,appropriate gelatin sponge particles embolization.Experimental group: on the basis of the control group,add 200 mg elemene injection perfusion + 400 mg elemene injection intravenous drip for one week.One intervention treatment is a course of treatment.Biochemical indicators,including blood routine,liver and kidney function,liver cancer tumor markers AFP and CEA,are detected before and one week after operation.Meanwhile,the quality of life,TCM symptoms,adverse reactions of patients are observed.At the end of each course of treatment,reexamination is conducted once every three months to evaluate the remission.All data were processed by spss21.0.Results :(1)Quality of life:After treatment,the score of the experimental group was significantly higher than that of the control group(P < 0.05).(2)Comparing the improvement of TCM symptoms:Compared with the control group,the symptoms of stupor and fatigue in the experimental group were significantly improved(P < 0.05),but the nausea and vomiting were not significantly improved(P > 0.05)..(3)Toxic Reactions :During the treatment period,the incidence of leucopenia,thrombocytopenia and liver function damage in the experimental group was lower than that in the control group,the difference was statistically significant(P < 0.05),and there was no significant difference between the two groups in the incidence of hemoglobin reduction and renal function damage(P >0.05).(4)Immune function: After treatment,the ratio of CD3 + T and CD4 + T in the experimental group was higher than that in the control group(P < 0.05),but there was no significant difference between the two groups(P > 0.05).(5)Tumor markers: There was no significant difference in AFP and CEA between the two groups(P >0.05).(6)Adverse reactions: The incidence of fever,pain and fatigue in the experimental group was lower than that in the control group(P < 0.05).(7)Tumor remission rate: The remission rate of the experimental group was higher than that of the control group(P <0.05).Conclusion(1)Elemene injection combined with TACE can improve the quality of life of patients and improve the symptoms of traditional Chinese medicine;(2)Elemene injection combined with TACE can slow down the incidence of myelosuppression and liver function damage,but there is no significant difference in renal function damage;(3)Elemene injection combined with TACE can reduce the adverse reactions of patients’ pain,fever,fatigue and other interventions;(4)Elemene injection combined with TACE can improve the immune function of patients;(5)Elemene injection combined with TACE can improve the remission rate of tumor. |