Study On The Correlation Between Serum Zinc-α2-glycoprotein And Gestational Diabetes Mellitus

BackgroundGestational diabetes mellitus(GDM)is defined as glucose intolerance of variable degrees with an onset,or first recognized,during pregnancy.It usually appears in the second and third trimester of pregnancy and is a common pregnancy complication.GDM seriously harms the health of mothers and infants.The incidence of GDM in China is increasing year by year.It is particularly important to explore and analyze the pathogenic factors of GDM and find predictive indicators.The etiology of GDM is not very clear.At Present,GDM is considered to be the result of a combination of factors such as heredity,insulin resistance,inflammatory factors,and adipokines.Zinc-alpha2-glycoprotein(ZAG)is a protein isolated and purified from human plasma.It has been proved to be an adipokine,which is involved in the regulation of obesity and lipid metabolism,and also has anti-diabetic effect.Related research on ZAG and GDM is rare.This study explored the correlation between serum ZAG and GDM,and provided new ideas for the recognition and treatment of GDM.ObjectiveBy measuring the expression levels of ZAG in GDM and normal glucose tolerance maternal serum,the correlation between ZAG and GDM was analyzed,and the relevant factors affecting ZAG levels were explored,as well as the predictive effects of GDM.Materials and methods80 patients with GDM patients who were examined in the third affiliated hospital of Zhengzhou University from July 2018 to June 2019 were selected as the observation group,and 80 healthy pregnant women were treated as the control group during the same period.Human body composition analysis was performed from 24 to 28 weeks of pregnancy,and oral glucose tolerance test(OGTT)test fasting blood was collected from 24 to 28 weeks of pregnancy.Serum ZAG levels and serum insulin levels were measured by enzyme-linked immunosorbent assay(ELISA).Collect and analysis of baseline data(age,weight before pregnancy,height,address,motherhood history,educational level),biochemical indicators during pregnancy,and follow-up of pregnant women’s pregnancy outcomes and then statistical analysis.The collected data was input into the SPSS21.0 data window for statistical analysis,all the test level was α=0.05.Results(1)Serum ZAG levels in the second trimester of the GDM group was lower than that in the control group.(2)Observation group serum ZAG levels decreased with the increase of pre-pregnancy BMI,the lowest in the obese group,followed by overweight group.(3)Serum ZAG levels in the second trimester is a protection factor for GDM(P<0.05).(4)Serum ZAG in the observation group was negatively correlated with BMI,FM,FPG at early pregnancy,TG at early pregnancy,FPG in second trimester,and TG in second trimester(P<0.05).(5)The areas under the curve for the diagnosis of GDM in serum ZAG in the second trimester were 0.763,the sensitivity was 85.1%,specificity was 59.8%.(6)There was no correlation between serum ZAG levels in second trimester and neonatal birth weight(P>0.05).ConclusionsSerum ZAG levels in pregnant women with GDM are reduced during the second trimester.Serum ZAG has certain predictive value for GDM.Which suggesting that ZAG is closely related to GDM and lipid metabolism.