Differences Between Bone And Lipid Metabolism In Postmenopausal Women With Type 2 Diabetes

Objective: This study explored the difference between the measured bone met abolism indexes and some lipid metabolism indexes by observing the changes of b one metabolism indexes and some lipid metabolism indexes in women with type 2diabetes after their natural post-menopause.Methods: A total of 147 women aged45-72 years with natural menopause≥2 years were selected and divided into 47 p atients with type 2 diabetes and 100 patients with non-type 2 diabetes according to the diagnostic criteria for type 2 diabetes;the same dual-energy X-ray absorptiom etry was used(DEXA)Scanner,perform bone mineral density(BMD)scan on the lumbar 3,lumbar 4 vertebral bodies and hips(femoral neck,Wards triangle gross t rochanter,gross trochanter)to obtain BMD and T values;Simultaneous determinat ion of glycated hemoglobin value,bone metabolism markers(type I collagen amino terminal elongation peptide PINP,β-collagen degradation product β-CTX),partial li pid metabolism markers(phosphatidylcholine PC,cardiolipin CL,sphingolipids SM),cortisol,androstenedione(Androstenedione)and other biochemical indicators,comp aring the differences in metabolic markers between the groups.Results: 1.Analysis o f bone metabolism markers,lipid metabolism markers,bone mineral density and T value between the type 2 diabetes group and the non-type 2 diabetes group showe d no statistical difference;2.the type 2 diabetes group had normal and abnormal gl ycated hemoglobin groups analysis of metabolic markers,lipid metabolism markers,bone mineral density and T value showed no statistical difference;3.on the premi se of different bone mass levels in type 2 diabetes group,the measured cortisol,P INP,CL(75:4)analysis,the results were not statistically significant;4.the results ofβ-CTX at different bone mass levels were statistically different(F=3.196,P=0.044),and β-CTX in the osteoporosis group were significantly higher than the bone mass reduction group compared with normal bone mass group;5.at different bone m ass levels,the analysis results of PC(18:0/20:4)are statistically different(F=183.528,P<0.001),and the trend is increasing with the decrease of bone mass level;6.PC(36:2)analysis results were statistically significant(F=101.891,P<0.001),the b one mass reduction group was significantly higher than normal bone mass and oste oporosis group;7.PC(36:5)analysis results There is a statistical difference(F=227.552,P<0.001),and it increases with the decrease of bone mass level;8.SM(The analysis results of d16:0/18:1)are statistically different(F=54.975,P<0.001),and show a decreasing trend with the decrease of bone mass level.Conclusion: Chang es in some lipid metabolism indicators suggest that there is a correlation between l ipid metabolism and bone metabolism,which can be used by clinicians to detect,prevent,and treat osteoporosis earlier by detecting changes in lipid metabolism indi cators,and reduce the causes of osteoporosis.complication.