Correlation Between Diabetic Macular Edema And Urinary Albumin In Patients With Severe NPDR And Early PDR

Objective: To study the relationship between the occurrence of DME and urinary albumin in T2DM patients with severe NPDR and early PDR,and to explore the risk factors of DME.Methods: From March 2019 to December 2019,96 patients with T2DM diagnosed as severe NPDR and early PDR through ophthalmic consultation during the hospitalization in the First Affiliated Hospital of Xinjiang Medical University were collected,and their basic data,biochemical indicators,and ophthalmic examinations were collected.Combining the results of fundus photography,FFA and OCT,the patients were divided into DME-free group and DME group,the morphological characteristics of DME were analyzed,and the baseline data and biochemical indicators of the two groups were compared.Then group them according to the UACR classification definition,and analyze the relationship between different UACR levels and the occurrence of DME.Statistical analysis was performed using SPSS22.0 statistical software.Results: In T2DM patients with severe NPDR and early PDR,there were 71 cases of DME,25 cases without DME,and the incidence of DME was 73.76%;univariate analysis found that the DME-free group and the DME group had gender,smoking history,and UACR.There were statistical differences(P <0.05);multivariate logistic regression analysis showed that UACR and DME were statistically different(OR = 1.009;95% CI 1,1.081).Further analysis of the relationship between the quantitative grouping of urine albumin and the occurrence of DME found that there was a statistically significant difference in the incidence of DME between the microalbuminuria group and the large albuminuria group and the normal albuminuria group(P≤0.017);There was no significant difference in the incidence of DME between the proteinuria group and the large albuminuria group(P> 0.017).Conclusion: The incidence of DME in T2DM patients with severe NPDR and early PDR was 73.76%;urine albumin was Independent risk factors for the occurrence of DME in T2DM patients with severe NPDR and early PDR,and the severity of urinary albumin is associated with the occurrence of DME;in T2DM patients with severe NPDR and early PDR,gender,smoking history may be related to DME.