Clinical And CT Imaging Characteristics Of EGFR Mutant In Lung Adenocarcinoma

Objective:This study retrospectively analyzed the relationship between epidermal growth factor receptor(EGFR)mutation status and clinical,CT imaging and tumor marker(CEA)characteristics in 426 patients with lung adenocarcinoma at the affiliated tumor hospital of xinjiang medical university.Methods:The chest CT manifestations,general clinical data and CEA expression level of 426 patients with lung adenocarcinoma were retrospectively evaluated.EGFR mutations in exon 18 to exon 21 were determined using the mutation amplification hindrance system(ARMS).multiple Logistic regression analysis was used to determine independent prognostic factors with EGFR mutation status.the backward elimination method was used to select the final model and the two regions under the characteristic.Results:Among 426 lung adenocarcinoma,210(49.31%)were positive for EGFR mutations.Most of the mutations occurred in :female patient(P<0.01);non-smoking patient(P<0.01);patients with stage I,stage II,high and moderate pathological differentiation;patients with high serum CEA level;patients with tumor lesions with lobulation sign,vacuole sign,air bronchus sign,vascular cluster sign,pleural depression sign and distant lymph node metastasis.Conclusion:CT imaging features of lung adenocarcinoma combined with clinical variables and CEA levels can better predict EGFR mutation status than using clinical variables alone.