| Objective:To explore the insulin requirement profiles and analyze the related factors of type 2 diabetics with different c-peptide levels on insulin pump therapy.Methods:Research object selection in December 2016 to December 2018 clinic of our hospital endocrinology,271 cases of patients with type 2 diabetes,the insulin pump intensive therapy during hospitalization,and summarizes the characteristics of insulin dosage,collect patients’general information,according to C2h/C0<2.5 ng/ml divided into c-peptide ratio is low,C2h/C0≥2.5 ng/ml for c-peptide ratio high group,and the quantity analysis before a meal quantity proportion of the differences and explore the related factors may affect the insulin dose.Results:The average insulin dose per kilogram（TDD）was（0.54±0.14）U/kg,and the proportion of basic insulin dose in patients with low C-peptide level was higher than that in patients with normal C-peptide level（P<0.05）.Pearson’s correlation analysis demonstrated that there was a correlation between the ratio of total basal insulin dose（TBD）to TDD（%TBa）and body mass index（BMI）（r=0.136,P<0.05）.There was a correlation between C2h/C0 and waist circumference（WC）,glycosylated hemoglobin A1c（HbA1c）,FBG and 2 h-postprandial blood glucose（2hBG）（r=-0.137,-0.154,-0.471,-0.172,all P<0.05）.Multiple linear regression analysis showed that BMI and FBG were independent factors of%TBa（β’=0.124,0.144,all P<0.05）,BMI and FBG were independent factors of C2h/C0（β’=-0.134,-0.502,all P<0.05）.Conclusion:The basal premeal dose ratio of type 2 diabetes mellitus with different C peptide levels was different when intensive insulin pump therapy.The ratio of total basal insulin dose to total bolus insulin dose is 50%:50%in Chinese type 2 diabetics with low C peptide level and that of patients with normal C peptide level was close to45%:55%.%TBa was related to FBG andβcell function and BMI.The base amount of insulin pump can be set according to the function of islet. |
PDF Full Text Request