Clinical Value Of Serum Interleukin-26 In Chronic Obstructive Pulmonary Disease

[Objective]To investigate the value of interleukin-26(IL-26)in evaluating the progress and prognosis of chronic obstructive pulmonary disease(COPD)by analyzing the serum levels of interleukin-26(IL-26)in patients with COPD at different stages and its correlation with other inflammatory,pulmonary function and prognosis indicators.[Methods]A total of 105 COPD patients admitted to Respiratory Department of Liyang People’s Hospital from February 2018 to April 2019 were included.At the same time,50 healthy volunteers confirmed by outpatient physical examination in the same period were selected as control group.According to the grouping criteria,COPD patients were divided into acute exacerbation group and stable group,with 50 cases and 55 cases respectively.The basic data and serum samples of all subjects were collected.Serum IL-26 and leptin levels were measured by double antibody sandwich enzyme-linked immunosorbent assay(ELISA),serum CRP level and white blood cell count were measured by biochemical analyzer.The nutritional indicators(body mass index),lung function indicators(FEV1%and FEV1/FVC)and quality of life indicators(SF-36 score)of all subjects were evaluated and compared.Pearson correlation analysis was used to evaluate the correlation between serum IL-26 levels and total scores of CRP,leptin,white blood cell count,BMI,FEV1%,FEV1/FVC and SF-36 in patients with acute exacerbation P<0.05 means that the difference is significant.[Results]There was no significant difference in age and sex distribution among the three groups(P>0.05),smoking index was significantly different(P<0.001),and the average duration of the acute exacerbation group was significantly longer than that of the stable group(P=0.006).The levels of serum IL-26,CRP,leptin and white blood cell count in acute exacerbation group were significantly higher than those in stable group and control group(P<0.05),while the levels of serum IL-26,CRP,leptin and white blood cell count in stable group were also significantly higher than those in control group(P<0.05).There was no significant difference in BMI among the three groups(P=0.157).The total scores of FEV1%and FEV1/FVC,SF-36 in the acute exacerbation group were significantly lower than those in the stable group and the control group(P<0.05),while the total scores of FEV1%and FEV1/FVC,SF-36 in the stable group were also significantly lower than those in the control group(P<0.05).Serum IL-26 levels in acute exacerbation group were positively correlated with serum CRP,leptin and white blood cell count(P<0.05),but not with BMI(P>0.05),and negatively correlated with total scores of FEV1%,FEV1/FVC and SF-36(P<0.05).[Conclusion]The levels of serum CRP,leptin and leukocyte count in COPD patients were significantly higher than those in healthy people,indicating that COPD patients were in a state of systemic inflammatory hyperresponsiveness,and the level of serum IL-26 was significantly higher than that in healthy people,and it was positively correlated with classical serum inflammatory markers,but not with BMI,indicating that IL-26 could be used as a marker of systemic inflammation.In order to reflect the inflammatory state of COPD in aggravated stage,it is not affected by obesity.The higher the level of serum IL-26,the worse the pulmonary function and quality of life,suggesting that IL-26 may be a potential new biomarker for the progression and prognosis of COPD.